Type 1 diabetes induced by immune checkpoint inhibitors
| Autor: | Rui Zhang, Xiao-Ling Cai, Liu Liu, Xue-Yao Han, Li-Nong Ji, Li-Shao Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Diabetic ketoacidosis
medicine.medical_treatment lcsh:Medicine Disease Human leukocyte antigen Immune checkpoint inhibitors 03 medical and health sciences 0302 clinical medicine Neoplasms Diabetes mellitus medicine Humans Immunologic Factors CTLA-4 Antigen Adverse effect Review Articles Type 1 diabetes business.industry Insulin Programmed cell death-1 lcsh:R General Medicine Immunotherapy medicine.disease Diabetes Mellitus Type 1 030220 oncology & carcinogenesis Immunology business 030217 neurology & neurosurgery |
| Zdroj: | Chinese Medical Journal, Vol 133, Iss 21, Pp 2595-2598 (2020) Chinese Medical Journal |
| ISSN: | 2542-5641 0366-6999 |
| DOI: | 10.1097/CM9.0000000000000972 |
| Popis: | With the increasing use of immune checkpoint inhibitors (ICI) including anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and anti-programmed cell death-1 (PD-1) in cancers, ICI-induced type 1 diabetes has been reported throughout the world. In this review, we aim to summarize the characteristics of this disease and discuss the mechanism of it. As an immune-related adverse event, type 1 diabetes developed after the administration of anti-PD-1 or anti-PD-ligand 1 (PD-L1) in the combination with or without anti-CTLA-4. It usually presented with acute onset, and 62.1% of the reported cases had diabetic ketoacidosis. Only a third of them had positive autoantibodies associated with type 1 diabetes. Susceptible HLA genotypes might be associated. T-cell-stimulation by blocking of the interaction of PD-1 and PD-L1 in pancreatic β cells was the main mechanism involved in the pathology. Insulin was the only effective treatment of ICI-induced type 1 diabetes. In conclusions, ICI-induced type 1 diabetes is a potentially life-threating adverse event after the immunotherapy of cancers. Screening and early recognition is important. Further investigation of the mechanism may help to better understand the pathology of type 1 diabetes. |
| Databáze: | OpenAIRE |
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