Subchronic treatment with grape-seed phenolics inhibits ghrelin production despite a short-term stimulation of ghrelin secretion produced by bitter-sensing flavanols
| Autor: | Inge Depoortere, Montserrat Pinent, Ximena Terra, Maria Teresa Blay, Joan Serrano, Àngela Casanova-Martí, Anna Ardévol |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty 030209 endocrinology & metabolism Stimulation Antioxidants Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stomach Neoplasms Cell Line Tumor Gallic Acid Internal medicine Orexigenic medicine Animals Vitis RNA Messenger Gallic acid Intestinal Mucosa 030109 nutrition & dietetics Dose-Response Relationship Drug Grape Seed Extract Stomach digestive oral and skin physiology Polyphenols Ghrelin Rats Intestines medicine.anatomical_structure Endocrinology Gene Expression Regulation chemistry Gastric Mucosa Cell culture Female hormones hormone substitutes and hormone antagonists Ghrelin secretion Food Science Biotechnology medicine.drug Hormone |
| Zdroj: | Molecular Nutrition & Food Research. 60:2554-2564 |
| ISSN: | 1613-4125 |
| Popis: | cope : Grape-seed phenolic compounds have recently been described as satiating agents in rats when administered as a whole phenolic extract (GSPE). This satiating effect may involve the release of satiating gut hormones such as GLP-1, although a short-term increase in the orexigenic hormone ghrelin was also reported. In this study we investigated the short and long-term effects of GSPE in rats, focusing on the role of the main grape-seed phenolics in ghrelin secretion. Methods and results : GSPE produced a short-term increase in plasma ghrelin in rats after an acute treatment. A mouse ghrelinoma cell line was used to test the effects of the main pure grape-seed phenolic compounds on ghrelin release. Monomeric flavanols stimulated ghrelin secretion by activating bitter taste receptors. In contrast, gallic acid (GA) and oligomeric flavanols inhibited ghrelin release. The ghrelin-inhibiting effects of GA were confirmed in rats and in rat duodenal segments. One day after the last dose of a subchronic treatment, GSPE decreased plasma ghrelin in rats, ghrelin secretion in intestinal segments and ghrelin mRNA expression in stomach. Conclusion : The sustained satiating effects of GSPE are related to a long-term decrease in ghrelin expression. GA and oligomeric flavanols play a ghrelin-inhibiting role in this process. This article is protected by copyright. All rights reserved |
| Databáze: | OpenAIRE |
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