Synthesis of Enantioenriched β-Hydroxy-γ-Acetal Enamides by Rhodium-Catalyzed Asymmetric Transfer Hydrogenation

Autor:	Anne Westermeyer, Gérard Guillamot, Virginie Ratovelomanana-Vidal, Phannarath Phansavath
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Acetal chemistry.chemical_element 010402 general chemistry Transfer hydrogenation 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis Rhodium chemistry.chemical_compound Physical and Theoretical Chemistry
Zdroj:	Organic letters. 22(10)
ISSN:	1523-7052
Popis:	The asymmetric reduction of β-keto-γ-acetal enamides has been investigated. A wide range of enantioenriched β-hydroxy-γ-acetal enamides were obtained through asymmetric transfer hydrogenation catalyzed by a tethered Rh(III)-DPEN complex with yields up to quantitative and enantioselectivities up to 99%. The reaction proved to be highly chemoselective toward the reduction of the carbonyl group over the C═C bond.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68d3c5eed09c5f7c92e2750ae9fb2e0 https://pubmed.ncbi.nlm.nih.gov/32330052 Zobrazit plný text záznamu