Biomarkers of tolerance: searching for the hidden phenotype
| Autor: | Maria P. Hernandez-Fuentes, Pervinder Sagoo, Esperanza Perucha, Irene Rebollo-Mesa |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
validation
medicine.medical_specialty Pathology Future studies tolerance business.industry immunosupression biomarkers Meeting Report renal transplantation Transplantation Nephrology Renal transplant Valid Biomarker Renal allograft Medicine Statistical analysis Biomarker discovery business Intensive care medicine |
| Zdroj: | Kidney International Supplements |
| ISSN: | 2157-1716 |
| DOI: | 10.1038/kisup.2011.11 |
| Popis: | Induction of transplantation tolerance remains the ideal long-term clinical and logistic solution to the current challenges facing the management of renal allograft recipients. In this review, we describe the recent studies and advances made in identifying biomarkers of renal transplant tolerance, from study inceptions, to the lessons learned and their implications for current and future studies with the same goal. With the age of biomarker discovery entering a new dimension of high-throughput technologies, here we also review the current approaches, developments, and pitfalls faced in the subsequent statistical analysis required to identify valid biomarker candidates. |
| Databáze: | OpenAIRE |
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