Neurobehavioural and cognitive effects of prenatal exposure to organochlorine compounds in three year old children

Autor: Greet Schoeters, Adrian Covaci, Gudrun Koppen, Vera Nelen, Mineke Viaene, Nik van Larebeke, Griet Vermeir
Přispěvatelé: Biology
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Context (language use)
010501 environmental sciences
01 natural sciences
Bayley Scales of Infant Development
Neutral (non-gender) behaviour
03 medical and health sciences
Cognition
Belgium
Pregnancy
Mental development
Hydrocarbons
Chlorinated
medicine
Humans
motor development
Prospective Studies
Pediatrics
Perinatology
and Child Health
Prospective cohort study
P
p’-dichlorodiphenyldichloroethylene (DDE)
0105 earth and related environmental sciences
Polychlorinated biphenyls (PCBs)
Intelligence quotient
business.industry
Confounding
lcsh:RJ1-570
Infant
Wechsler Adult Intelligence Scale
lcsh:Pediatrics
Dioxin-like substances
Environmental Exposure
030104 developmental biology
Child
Preschool
Prenatal Exposure Delayed Effects
Pediatrics
Perinatology and Child Health
cord blood
Anxiety
Environmental Pollutants
Female
Hexachlorobenzene (HCB)
Human medicine
medicine.symptom
business
Research Article
Demography
Play behaviour
Zdroj: BMC pediatrics
BMC Pediatrics
BMC Pediatrics, Vol 21, Iss 1, Pp 1-15 (2021)
ISSN: 1471-2431
Popis: Background We report data of a Belgian observational prospective cohort study regarding cognitive and behavioural development until the age of 36 months in relation to internal exposure to organochlorine pollutants [sum of polychlorinated biphenyls (sum PCB), dioxin-like activity, PCB118, PCB170, hexachlorobenzene (HCB) and p,p’-dichlorodiphenyldichloroethylene (DDE)] measured in cord blood. Methods Participants were recruited as part of an Flemish Environmental Health Survey (2002–2006). Two hundred and six mother-child pairs were recruited. Hundred twenty five toddlers [Reynell Taal Ontwikkelings Schalen (language development, RTOS), Snijders-Oomen Niet-verbale intelligentietest (non-verbal intelligence, SON), Bayley Scales, milestones, Infant Behaviour Questionnaire (IBQ), gender specific play behaviour, Neurobehavioral Evaluation System (NES)-attentional task] and their mothers [Home Observation Measurement of the Environment (HOME), Wechsler Abbreviated Scale of Intelligence (WASI), State-Trait Anxiety Inventory (STAI), general questionnaires] were tested. Statistical analysis was performed with the SPSS program. Much attention was paid to confounding factors. Results In the first years of development, higher organochlorine pollutants were associated with less active children (delayed crawling: sum PCB*HCB (p p p p p p Conclusion Our data confirm the observations that neurobehavioral development of young children is adversely influenced by environmental concentrations of PCBs, especially in boys. In this context, observation of play behaviour seems to be a reliable, easy to perform and sensitive test to detect neurotoxic effects of chemicals like PCB’s and dioxin-like compounds in very young children. On the basis of our results, we hypothesize that an underarrousal pattern may play a role in the spectrum of effects measured in toddlers prenatally exposed to PCBs and dioxin-like compounds.
Databáze: OpenAIRE
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