SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN MACULA-INVOLVING CYTOMEGALOVIRUS RETINITIS
| Autor: | Anton Orlin, Donald J DʼAmico, Jennifer Nadelmann, R.V. Paul Chan, Sarju Patel, Szilard Kiss, Ru Ik Chee, Elizabeth Marlow, Mrinali P. Gupta |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Visual Acuity Retinitis Fundus (eye) Posterior vitreous detachment Retina Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Humans Original Study Macula Lutea ellipsoid zone Fluorescein Angiography External limiting membrane Retrospective Studies optical coherence tomography business.industry Epiretinal Membrane Retinal General Medicine Middle Aged medicine.disease external limiting membrane eye diseases disruption of the inner retinal layers Vitreous Body medicine.anatomical_structure chemistry Cytomegalovirus Retinitis Disease Progression 030221 ophthalmology & optometry Female sense organs Cytomegalovirus retinitis Epiretinal membrane business Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | Retina (Philadelphia, Pa.) |
| ISSN: | 0275-004X |
| DOI: | 10.1097/iae.0000000000001644 |
| Popis: | The authors retrospectively reviewed spectral domain optical coherence tomography (OCT) findings in 10 eyes with macula-involving cytomegalovirus retinitis. Optical coherence tomography findings were longitudinally evaluated in three areas: within the area of active retinitis, at the leading edge of retinitis, and in the retina just beyond the leading edge of retinitis. Purpose: To evaluate the microstructural features of cytomegalovirus (CMV) retinitis by spectral domain optical coherence tomography (OCT). Methods: Subjects were patients with macula-involving CMV retinitis with OCT imaging. The leading edge of retinitis in the macula was identified based on fundus imaging, and OCT findings were longitudinally evaluated in three areas: within the area of active retinitis, at the leading edge of retinitis, and just beyond the leading edge of retinitis. Results: Optical coherence tomography imaging of macular CMV retinitis identified vitreous cells in 10 eyes (100%), posterior vitreous detachment in four eyes (40%), broad-based vitreomacular traction in one eye (10%), epiretinal membrane in eight eyes (80%), and lamellar hole–associated epiretinal proliferation associated with an atrophic hole in one eye (10%). Retinal architectural disruption, disruption of inner retinal layers, disruption of the external limiting membrane, and ellipsoid zone abnormalities were noted within the area of retinitis in all eyes and decreased in frequency and severity at and beyond the leading edge of retinitis, although all 10 eyes (100%) exhibited one of these abnormalities, especially outer retinal microabnormalities, beyond the leading edge of retinitis. Conclusion: Microstructural abnormalities were frequently noted on OCT of CMV retinitis, including within the retina beyond the leading edge of retinitis identified by corresponding fundus imaging. Outer retinal abnormalities were noted more frequently than inner retinal abnormalities beyond the leading edge of retinitis. These findings provide insight into the effects of CMV retinitis on retinal microstructure and potentially on vision and highlight the potential utility of OCT for monitoring microprogression of macula-involving CMV retinitis. |
| Databáze: | OpenAIRE |
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