Urinary Bone Resorption Markers (Deoxypyridinoline and C-Terminal Telopeptide of Type I Collagen) in Healthy Persons, Postmenopausal Osteoporosis and Patients with Type I Diabetes
| Autor: | Walter Josef Fassbender, V M Brandenburg, Ulla Stumpf, K H Usadel, M Gödde |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Deoxypyridinoline medicine.medical_specialty Bone density Urinary system Osteoporosis Enzyme-Linked Immunosorbent Assay Urine Gastroenterology Collagen Type I Bone resorption Young Adult chemistry.chemical_compound N-terminal telopeptide Bone Density Internal medicine Confidence Intervals Humans Medicine Amino Acids Bone Resorption Osteoporosis Postmenopausal Aged Aged 80 and over business.industry General Medicine Middle Aged medicine.disease C-terminal telopeptide Diabetes Mellitus Type 1 Endocrinology chemistry Luminescent Measurements Regression Analysis Female Peptides business Biomarkers |
| Zdroj: | Advances in Medical Sciences. 54:1-6 |
| ISSN: | 1898-4002 1896-1126 |
| Popis: | Purpose: Deoxypyridinoline (DPD) is a derivative of hydroxypyridinium, which is released during bone resorption into the blood stream and is eliminated unmodified with urine. A further collagen-derived marker of bone resorption is the C-terminal telopeptide of type I collagen (β-CTX-I, here abbreviated as CTX), which is released in bone resorption and almost entirely excreted by the kidneys. The aim of our study was to investigate different well-described patient groups as well as normal probands in view of differences and expected correlations of these two parameters: patients with insulin-dependent diabetes mellitus, postmenopausal women with osteoporosis and healthy control persons. Materials and Methods: We used a solid-phase chemiluminescence enzyme immunoassay (Pyrilinks D-IMMULITE) for urinary DPD measurement and for the assessment of urinary CTX we used a quantitative ELISA (Osteometer Biotec A-S, CrossLaps® ELISA). Results: We found a highly significant correlation between both parameters in the group of healthy persons (r = 0.75, p < 0.05, n = 28) as well as in the group of patients with diabetes mellitus type I (r = 0.79, p < 0.05, n = 65). Also, a significant correlation was observed between DPD and CTX (r = 0.583, p < 0.05, n = 88) in the group of female osteoporotic patients. Conclusions: Despite good correlations between DPD and CTX in all of the investigated groups, these urinary markers were of limited diagnostic significance in the group of postmenopausal osteoporosis due to a wide spread (few patients showed concentrations above the range of healthy persons) in this newly diagnosed drug-naive patient collective. |
| Databáze: | OpenAIRE |
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