Chitosan-hyaluronan/nano chondroitin sulfate ternary composite sponges for medical use
| Autor: | Shantikumar V. Nair, Annapoorna Mohandas, Rangasamy Jayakumar, Krishna Prasad Chennazhi, Deepthi Sankar, B.S. Anisha |
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| Rok vydání: | 2012 |
| Předmět: |
Polymers and Plastics
Cell Survival Composite number Nanoparticle Biocompatible Materials Cell Line Chitosan chemistry.chemical_compound Materials Chemistry medicine Cell Adhesion Humans Chondroitin sulfate Platelet activation Composite material Hyaluronic Acid Blood Coagulation Cell Proliferation Nanocomposite integumentary system biology Organic Chemistry Chondroitin Sulfates Water Fibroblasts biology.organism_classification Platelet Activation Bandages Nanostructures Sponge chemistry Swelling medicine.symptom Porosity Nuclear chemistry |
| Zdroj: | Carbohydrate polymers. 92(2) |
| ISSN: | 1879-1344 |
| Popis: | In this work chitosan-hyaluronan composite sponge incorporated with chondroitin sulfate nanoparticle (nCS) was developed. The fabrication of hydrogel was based on simple ionic cross-linking using EDC, followed by lyophilization to obtain the composite sponge. nCS suspension was characterized using DLS and SEM and showed a size range of 100-150 nm. The composite sponges were characterized using SEM, FT-IR and TG-DTA. Porosity, swelling, biodegradation, blood clotting and platelet activation of the prepared sponges were also evaluated. Nanocomposites showed a porosity of 67% and showed enhanced swelling and blood clotting ability. Cytocompatibility and cell adhesion studies of the sponges were done using human dermal fibroblast (HDF) cells and the nanocomposite sponges showed more than 90% viability. Nanocomposite sponges also showed enhanced proliferation of HDF cells within two days of study. These results indicated that this nanocomposite sponges would be a potential candidate for wound dressing. |
| Databáze: | OpenAIRE |
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