Hypoglycaemic activity of Mathurameha, a Thai traditional herbal formula aqueous extract, and its effect on biochemical profiles of streptozotocin-nicotinamide-induced diabetic rats
| Autor: | Penchom Peungvicha, Piyanuch Rojsanga, Kullacha Chayarop, Rungravi Temsiririrkkul, Wongsatit Chuakul, Yuvadee Wongkrajang |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Niacinamide 0301 basic medicine Herbal formula medicine.medical_treatment Intraperitoneal injection Type 2 diabetes Pharmacology Streptozocin Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Diabetes mellitus 0302 clinical medicine Hypoglycaemic activity Oral administration medicine Animals Humans Hypoglycemic Agents Triglycerides Acute toxicity Plant Extracts business.industry lcsh:Other systems of medicine General Medicine Plants lcsh:RZ201-999 Thailand medicine.disease Streptozotocin Rats Cholesterol 030104 developmental biology Postprandial Diabetes Mellitus Type 2 Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Uric acid Female Thai traditional medicine business Research Article Mathurameha medicine.drug |
| Zdroj: | BMC Complementary and Alternative Medicine BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-11 (2017) |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/s12906-017-1851-8 |
| Popis: | Background The Thai traditional herbal formula–Mathurameha, consisting of 26 medicinal plants, has been used as an alternative and complementary medicine for diabetes treatment in Wangnamyen Hospital, Thailand. To provide scientific evidences on the efficacy and safety of this herbal formula, in vivo hypoglycaemic activity, effect on serum biochemical profiles and acute toxicity were investigated. Methods Experimental type 2 diabetes was induced in male Sprague-Dawley rats by intraperitoneal injection of nicotinamide 15 min prior to intravenous injection of streptozotocin. The most effective extract from the oral glucose tolerant test (OGTT) was administered daily via the oral route to diabetic rats for 2 weeks. Two-hour postprandial plasma glucose (2h–PPG) levels were measured on days 0, 7, and 14. Biochemical data were measured at the end of daily oral administration experiment. Results Aqueous extract of the herbal formula was the most potent extract for improving glucose tolerance of streptozotocin-nicotinamide-induced diabetic rats after single oral administration. After 2 weeks of daily oral administration, the aqueous extract showed a dose-dependent glucose lowering effect. At doses of 12.5, 25, and 50 mg/kg, the 2h–PPG level of diabetic rats decreased by 3.32%, 15.78%, and 17.94%, respectively. Most of the biochemical profiles of diabetic rats were improved, including the total cholesterol (TC), alkaline phosphatase (ALP), total protein, albumin, globulin, creatinine, and uric acid levels. The significantly increased triglyceride (TG) level observed in treated diabetic rats indicated a lack of a beneficial effect of the extract on lipid homeostasis. Nevertheless, there were no signs or symptoms of acute toxicity observed after oral administration of aqueous extract (5 g/kg) to both male and female rats. Conclusions The results revealed that the herbal formula aqueous extract has hypoglycaemic activity, beneficial effects on biochemical profiles and a lack of acute toxicity. This study confirms the efficacy and safety of the Mathurameha herbal formula used for treating type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
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