Effects of maternal high-fat diet and statin treatment on bone marrow endothelial progenitor cells and cardiovascular risk factors in female mice offspring fed a similar diet

Autor: Maqsood M. Elahi, Bashir M. Matata
Rok vydání: 2016
Předmět:
0301 basic medicine
medicine.medical_specialty
Statin
medicine.drug_class
Offspring
Endocrinology
Diabetes and Metabolism
Hypercholesterolemia
Blood Pressure
030204 cardiovascular system & hematology
Biology
Diet
High-Fat
03 medical and health sciences
Mice
0302 clinical medicine
Bone Marrow
Pregnancy
Risk Factors
Internal medicine
Lactation
medicine
Weaning
Animals
Obesity
Triglycerides
Adiposity
Endothelial Progenitor Cells
Nutrition and Dietetics
medicine.diagnostic_test
Body Weight
Cholesterol
HDL
nutritional and metabolic diseases
Cholesterol
LDL
Maternal Nutritional Physiological Phenomena
medicine.disease
Mice
Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
Endocrinology
C-Reactive Protein
Hypertension
lipids (amino acids
peptides
and proteins)
Female
Bone marrow
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipid profile
Pravastatin
medicine.drug
Zdroj: NUTRITION
ISSN: 1873-1244
Popis: Objectives The aim of this study was to prove that one possible statin-related protective mechanism in dams and offspring fed a high-fat diet (HFD) is the reduction in cardiovascular risk and impairment of the vasculogenic element of endothelial regeneration. Methods To explore this, virgin C57 BL/6 mice (n = 8/group) were fed an HFD (fat: 45% kcal) or standard chow (C; fat: 21% kcal) from weaning and throughout their pregnancy and lactation. Half of the HFD group also was given the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin (S) through their drinking water (5 mg/kg body weight per day) to create HF+S dam group (n = 8/group). Offspring from each group were fed HFD or C diet from weaning to adulthood, generating respective dam/offspring dietary groups (C/C, HF/HF, HF+S/HF; n = 8/group). Body weight, blood pressure, and serum lipid profile were measured in female offspring at age 24 wk, and bone marrow endothelial progenitor cells (EPCs) were cultured. Results The results indicated that in the female offspring, the statin-fed (HF+S/HF) cohort had lower total and low-density lipoprotein cholesterol concentrations, were less obese and hypertensive, and had reduced C-reactive proteins (CRPs) compared with the HF/HF phenotype. The results also showed an increased bone marrow EPCs expressing colony numbers ( P Conclusions Results from the present study demonstrated that statin administration in early life to dams fed on a HFD had a significant effect on their female offspring in terms of reduction in cardiovascular risk factors. Additionally, statin administration to female offspring on an HFD during early life was associated with reduction in circulating CRPs and an increased bone marrow EPC numbers and colony-forming characteristics.
Databáze: OpenAIRE
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