C-Reactive Protein, Inflammatory Conditions, and Cardiovascular Disease Risk
Autor: | Ravi Dhingra, Peter W.F. Wilson, Byung-Ho Nam, Philimon Gona, Emelia J. Benjamin, Ralph B. D'Agostino, Christopher J. O'Donnell |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty Arthritis Inflammation Risk Assessment Article Prevalence medicine Humans Prospective Studies Risk factor Aged Proportional Hazards Models biology Extramural business.industry C-reactive protein Acute-phase protein General Medicine Middle Aged medicine.disease United States C-Reactive Protein Cross-Sectional Studies Logistic Models Cardiovascular Diseases Immunology biology.protein Disease risk Female medicine.symptom Risk assessment business |
Zdroj: | The American Journal of Medicine. 120:1054-1062 |
ISSN: | 0002-9343 |
Popis: | It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community.We evaluated 3782 Framingham Offspring Study participants (mean age 55 years; 52% women) free of baseline cardiovascular disease. Logistic regression models examined the prevalence of common inflammatory conditions by CRP categories, while a separate matched case-referent analysis evaluated the prevalence of uncommon inflammatory conditions. Cox models were used to assess the influence of common inflammatory conditions on relations between CRP and incident cardiovascular disease.Common inflammatory conditions were reported by nearly half of the participants; these individuals were more likely to have markedly high CRP concentrations (10 mg/L, P for trend=.001). In multivariable models, there were increased odds of having at least one common inflammatory condition with CRP concentrations of 1-3.0, 3.01-10, and10 mg/L, compared with the referent category (1 mg/L); the respective odds ratios with 95% confidence intervals were 1.41 (1.07-1.86), 1.45 (1.07-1.98), and 1.64 (1.09-2.47) in men, and 1.08 (0.82-1.43), 1.07 (0.80-1.44), and 1.38 (0.97-1.96) in women. In case-referent analyses, uncommon inflammatory conditions were more common in individuals with CRP10 mg/L compared with those with CRP1 mg/L (12.1% vs 6.6%; P=.0001). In multivariable models, higher CRP categories were not associated with incident cardiovascular disease, and with additional adjustment for inflammatory conditions, results remained unchanged.There is high prevalence of common and uncommon inflammatory conditions in individuals with high CRP concentrations. Higher CRP concentrations should be interpreted with caution in cardiovascular disease risk assessment. |
Databáze: | OpenAIRE |
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