Risk Assessment of Cadmium Toxicity on Hepatic and Renal Tissues of Rats
| Autor: | Eliane Passarelli Vieira, B. O. Ribas, Ethel L. B. Novelli, N.L Rodrigues |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty chemistry.chemical_element Cadmium chloride Kidney Risk Assessment Biochemistry Superoxide dismutase chemistry.chemical_compound Cadmium Chloride Superoxides Internal medicine medicine Animals Bioassay Rats Wistar General Environmental Science Creatinine Cadmium biology Superoxide Dismutase Chemistry Alanine Transaminase Bilirubin Rats Proteinuria medicine.anatomical_structure Endocrinology Liver Alanine transaminase Toxicity biology.protein |
| Zdroj: | Environmental Research. 79:102-105 |
| ISSN: | 0013-9351 |
| DOI: | 10.1006/enrs.1998.3865 |
| Popis: | Pollution and industrial practices result in concentrations of metals and other environmental agents that are related to environmental toxicity. A rat bioassay was utilized for the identification of toxic effects of cadmium intake. This demonstrated increased total urinary proteins and increased kidney weights in rats exposed to CdCl2 for 7 days, in drinking water (100 mg/L). Serum creatinine, total and direct bilirubin concentrations and alanine transaminase activity were increased in Cd-exposed rats, indicating renal and hepatic toxicity. It was also observed that lipoperoxide concentrations were increased, while Cu-Zn superoxide dismutase activity was decreased in rats treated with cadmium. This indicated that the renal and hepatic toxicity induced by cadmium involved superoxide radicals. |
| Databáze: | OpenAIRE |
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