Cytotoxic lesions of the corpus callosum in children: Etiology, clinical and radiological features, and prognosis
Autor: | Saliha Çıracı, Gonca Bektaş, Büşra Kutlubay, Sevinç Kalın, Esra Şevketoğlu, Hatice Gülhan Sözen, Özge Yapıcı, Hülya Maraş Genç, Bülent Kara, Zeynep Gör, Tuğçe Aksu Uzunhan, Nafiye Emel Çakar, Figen Palabıyık |
---|---|
Přispěvatelé: | Uzunhan T. A., Genc H. M., Kutlubay B., Kalin S., Bektas G., YAPICI Ö., Ciraci S., Sozen H. G., Sevketoglu E., Palabiyik F., et al. |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Pathology Corpus callosum Sağlık Bilimleri Pediatrics Clinical Medicine (MED) Corpus Callosum Nöroloji (klinik) Epilepsy Nöroloji Central Nervous System Infections 0302 clinical medicine Klinik Tıp (MED) Pediatri Perinatoloji ve Çocuk Sağlığı Child Brain Diseases Klinik Tıp Cytotoxic lesions of the corpus callosum (CLOCCs) Life Sciences ENCEPHALOPATHY General Medicine MILD ENCEPHALITIS/ENCEPHALOPATHY Systemic Inflammatory Response Syndrome Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) Tıp Urea cycle defect Neurology Child Preschool Reversible splenial lesion syndrome (RESLES) Acute disseminated encephalomyelitis Medicine Female PEDİATRİ Splenial medicine.medical_specialty Adolescent Diffusion-weighted magnetic resonance imaging (MRI) CLINICAL NEUROLOGY Çocuk Sağlığı ve Hastalıkları Child Health and Diseases 03 medical and health sciences Developmental Neuroscience Intensive care Saposin B deficiency Health Sciences Yaşam Bilimleri medicine Humans Apparent life-threatening event (ALTE) Retrospective Studies KLİNİK NÖROLOJİ Internal Medicine Sciences business.industry Infant COVID-19 Sequela Dahili Tıp Bilimleri CLINICAL MEDICINE REVERSIBLE SPLENIAL LESION medicine.disease Systemic inflammatory response syndrome Diffusion Magnetic Resonance Imaging Pediatri Pediatrics Perinatology and Child Health Etiology Neurology (clinical) business 030217 neurology & neurosurgery |
Popis: | Objectives Cytotoxic lesions of the corpus callosum (CLOCCs) are secondary lesions associated with entities like infection manifested by restricted diffusion on diffusion-weighted cranial magnetic resonance imaging. Our objectives are to evaluate the clinic-radiological spectrum of pediatric patients with cytotoxic lesions of the corpus callosum (CC). Methods Children (0–18 years) admitted between February 2017 and May 2020 with splenial lesions showing diffusion restriction on MRI, either isolated or within involvement of other parts of the brain, were included retrospectively. The primary lesions of the CC (e.g. acute disseminated encephalomyelitis, acute ischemic infarction, and glioblastoma multiforme) were excluded. CLOCCs were divided into infection-associated, metabolic disorder–associated, and trauma-associated lesions, as well as CLOCCs involving other entities. Data were collected from the medical databases. Results Forty-one patients were determined to have CLOCCs. Twenty-five (61%) were infection-associated, nine (22%) were trauma-associated, and three (7%) were metabolic disorder–associated cases, including 2 inherited disorders of metabolism. There were four (10%) patients with other entities, three with epilepsy, and one had an apparent life-threatening event. Six patients had a known etiology among the infection-associated group; one had multisystem inflammatory syndrome caused by COVID-19 and one had been infected by COVID-19 without any complications. All the infection-associated patients with isolated splenial lesions recovered totally, although six patients required intensive care hospitalization. Four trauma-associated patients had sequela lesions. Conclusions CLOCCs are associated with a spectrum of diseases, including the new coronavirus, COVID-19 infection. Infection-associated CLOCCs has the best prognosis, although severe cases may occur. Sequelae are possible based on the etiology. |
Databáze: | OpenAIRE |
Externí odkaz: |