Cytotoxic lesions of the corpus callosum in children: Etiology, clinical and radiological features, and prognosis

Autor: Saliha Çıracı, Gonca Bektaş, Büşra Kutlubay, Sevinç Kalın, Esra Şevketoğlu, Hatice Gülhan Sözen, Özge Yapıcı, Hülya Maraş Genç, Bülent Kara, Zeynep Gör, Tuğçe Aksu Uzunhan, Nafiye Emel Çakar, Figen Palabıyık
Přispěvatelé: Uzunhan T. A., Genc H. M., Kutlubay B., Kalin S., Bektas G., YAPICI Ö., Ciraci S., Sozen H. G., Sevketoglu E., Palabiyik F., et al.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Pathology
Corpus callosum
Sağlık Bilimleri
Pediatrics
Clinical Medicine (MED)
Corpus Callosum
Nöroloji (klinik)
Epilepsy
Nöroloji
Central Nervous System Infections
0302 clinical medicine
Klinik Tıp (MED)
Pediatri
Perinatoloji ve Çocuk Sağlığı

Child
Brain Diseases
Klinik Tıp
Cytotoxic lesions of the corpus callosum (CLOCCs)
Life Sciences
ENCEPHALOPATHY
General Medicine
MILD ENCEPHALITIS/ENCEPHALOPATHY
Systemic Inflammatory Response Syndrome
Mild encephalitis/encephalopathy with reversible splenial lesion (MERS)
Tıp
Urea cycle defect
Neurology
Child
Preschool

Reversible splenial lesion syndrome (RESLES)
Acute disseminated encephalomyelitis
Medicine
Female
PEDİATRİ
Splenial
medicine.medical_specialty
Adolescent
Diffusion-weighted magnetic resonance imaging (MRI)
CLINICAL NEUROLOGY
Çocuk Sağlığı ve Hastalıkları
Child Health and Diseases
03 medical and health sciences
Developmental Neuroscience
Intensive care
Saposin B deficiency
Health Sciences
Yaşam Bilimleri
medicine
Humans
Apparent life-threatening event (ALTE)
Retrospective Studies
KLİNİK NÖROLOJİ
Internal Medicine Sciences
business.industry
Infant
COVID-19
Sequela
Dahili Tıp Bilimleri
CLINICAL MEDICINE
REVERSIBLE SPLENIAL LESION
medicine.disease
Systemic inflammatory response syndrome
Diffusion Magnetic Resonance Imaging
Pediatri
Pediatrics
Perinatology and Child Health

Etiology
Neurology (clinical)
business
030217 neurology & neurosurgery
Popis: Objectives Cytotoxic lesions of the corpus callosum (CLOCCs) are secondary lesions associated with entities like infection manifested by restricted diffusion on diffusion-weighted cranial magnetic resonance imaging. Our objectives are to evaluate the clinic-radiological spectrum of pediatric patients with cytotoxic lesions of the corpus callosum (CC). Methods Children (0–18 years) admitted between February 2017 and May 2020 with splenial lesions showing diffusion restriction on MRI, either isolated or within involvement of other parts of the brain, were included retrospectively. The primary lesions of the CC (e.g. acute disseminated encephalomyelitis, acute ischemic infarction, and glioblastoma multiforme) were excluded. CLOCCs were divided into infection-associated, metabolic disorder–associated, and trauma-associated lesions, as well as CLOCCs involving other entities. Data were collected from the medical databases. Results Forty-one patients were determined to have CLOCCs. Twenty-five (61%) were infection-associated, nine (22%) were trauma-associated, and three (7%) were metabolic disorder–associated cases, including 2 inherited disorders of metabolism. There were four (10%) patients with other entities, three with epilepsy, and one had an apparent life-threatening event. Six patients had a known etiology among the infection-associated group; one had multisystem inflammatory syndrome caused by COVID-19 and one had been infected by COVID-19 without any complications. All the infection-associated patients with isolated splenial lesions recovered totally, although six patients required intensive care hospitalization. Four trauma-associated patients had sequela lesions. Conclusions CLOCCs are associated with a spectrum of diseases, including the new coronavirus, COVID-19 infection. Infection-associated CLOCCs has the best prognosis, although severe cases may occur. Sequelae are possible based on the etiology.
Databáze: OpenAIRE