Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration
| Autor: | Yue Ruan, Roman Hovorka, Ruben H. Willemsen, Malgorzata E. Wilinska, David B. Dunger, Martin Tauschmann |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent type 1 diabetes Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Mixed meal mixed‐meal tolerance test Diagnostic Techniques Endocrine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Insulin-Secreting Cells Area under curve Insulin Secretion Internal Medicine medicine Humans Secretion 030212 general & internal medicine Child Meals Glycated Hemoglobin Type 1 diabetes C-Peptide C-peptide business.industry C‐peptide Type 1 Diabetes: Pathophysiology and Prevention medicine.disease Postprandial Period beta‐cell secretion Endocrinology Postprandial Diabetes Mellitus Type 1 chemistry Area Under Curve Pediatrics Perinatology and Child Health Feasibility Studies Female Glycated hemoglobin Beta cell business |
| Zdroj: | Pediatric Diabetes |
| ISSN: | 1399-5448 |
| Popis: | Aims Residual beta‐cell secretion in type 1 diabetes is commonly assessed by area‐under‐curve of plasma C‐peptide concentration (AUCCpep) following mixed‐meal tolerance test (MMTT). We aimed to investigate alternative measures of beta‐cell responsiveness. Methods We analyzed data from 32 youth (age 7 to 17 years) undergoing MMTT within 6 months of type 1 diabetes diagnosis. We related AUCCpep with (a) validated mechanistic index of postprandial beta‐cell responsiveness M I accounting for glucose level during MMTT, and (b) pragmatic marker calculated as baseline plasma C‐peptide concentration corrected for baseline plasma glucose concentration. Results Postprandial responsiveness M I was correlated with age and BMI SDS (R s = 0.66 and 0.44, P < 0.01 and P < 0.05) and was more correlated with glycated hemoglobin than AUCCpep (R s = 0.79, P = 0.04). The pragmatic marker was highly correlated with AUCCpep (R s = 0.94, P < 0.01). Conclusions Postprandial responsiveness M I may be more relevant to glucose control than AUCCpep. Baseline C‐peptide corrected for baseline glucose appears to be a suitable surrogate of AUCCpep if MMTT is not performed. |
| Databáze: | OpenAIRE |
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