Prognostic value of early 18 fluorodeoxyglucose positron emission tomography and gallium-67 scintigraphy in aggressive lymphoma: a prospective comparative study

Autor:	Stéphane Bardet, Nicolas Aide, Odile Switsers, Christophe Fruchart, Oumedaly Reman, Levaltier X, Mélanie Liegard, Nolwenn Le Stang, Dada Musafiri, Stéphane Cheze, A. M. Peny, Margaret Macro, Michel Leporrier
Rok vydání:	2006
Předmět:	Adult Male Cancer Research medicine.medical_specialty Vincristine Lymphoma Aggressive lymphoma Gallium Radioisotopes CHOP Gastroenterology Sensitivity and Specificity Prednisone Fluorodeoxyglucose F18 hemic and lymphatic diseases Internal medicine medicine Humans Prospective Studies Aged Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Hematology Middle Aged medicine.disease Prognosis Non-Hodgkin's lymphoma Oncology Positron emission tomography Positron-Emission Tomography Vindesine Female Radiopharmaceuticals business Nuclear medicine medicine.drug
Zdroj:	Leukemialymphoma. 47(12)
ISSN:	1042-8194
Popis:	The prognostic value of fluorodeoxyglucose positron emission tomography (FDG-PET) and gallium-67 scan (GS) performed early after chemotherapy was assessed in 40 patients with newly diagnosed aggressive lymphoma. FDG-PET and GS were performed before and after three cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or two cycles of ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone), with or without rituximab. Thirty-five patients had diffuse large B-cell lymphoma (DLBCL), two had mantle-cell lymphoma and three had T-cell lymphoma. Four patients relapsed despite early negative FDG-PET and GS including all three patients with T-cell lymphoma. Nine patients stayed in remission despite positive FDG-PET and/or GS of whom five showed moderate intensity residual bone uptake. Seven of these nine early false positives had a negative exam at the end of treatment. In patients with DLBCL, the 2-year event-free survival was 85% for negative versus 30% for positive FDG-PET patients (P = 0.003) whereas it was 78% for negative versus 33% for positive GS patients (P = 0.018). Sensitivity, specificity and diagnostic accuracy of FDG-PET and GS were not significantly different: 90% versus 70%, 76 versus 80% and 80 versus 77%, respectively. We conclude that both FDG-PET and GS are valuable tools to early predict outcome in patients with DLBCL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67c980c536dac312d62e4ad153e6706 https://pubmed.ncbi.nlm.nih.gov/17169787 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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