p-Cresol inhibits IL-12 production by murine macrophages stimulated with bacterial immunostimulant
| Autor: | Masaharu Onoue, Ikuo Kato, Koji Kawakami, Ikuyo Makino, Kazumi Uchida |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Lactobacillus casei Immunology Toxicology Microbiology Cresols Mice chemistry.chemical_compound Immune system parasitic diseases Aromatic amino acids Animals Immunology and Allergy Macrophage Cytotoxicity Cells Cultured Pharmacology Mice Inbred BALB C biology Macrophages General Medicine biology.organism_classification Interleukin-12 In vitro Lacticaseibacillus casei chemistry Cell culture Interleukin 12 Kidney Failure Chronic Immunization |
| Zdroj: | Immunopharmacology and Immunotoxicology. 31:304-309 |
| ISSN: | 1532-2513 0892-3973 |
| DOI: | 10.1080/08923970802680299 |
| Popis: | p-Cresol, an end product of aromatic amino acids, is produced from food proteins by intestinal bacteria, and is detectable in blood and feces. Especially, blood and fecal levels of p-cresol are high in chronic renal failure (CRF) patients. Although it has been suggested that p-cresol is toxic in the body, the effect of p-cresol on immune responses has not yet been clarified. In this study, we investigated the effect of p-cresol on IL-12 production of macrophages stimulated with Lactobacillus casei strain Shirota (LcS) in vitro. Pre-incubation with p-cresol inhibited IL-12 p40 production of LcS-stimulated J774.1 cells, a murine macrophage-like cell line, in a dose-dependent manner. IL-12 p40 and p70 production of LcS-stimulated murine peritoneal macrophages was also inhibited by p-cresol. The inhibitory effect was not dependent on the cytotoxicity of p-cresol. These results indicate that blood and fecal p-cresol may have adverse effects on the host defense system in CRF patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |