Extrauterine growth restriction in preterm infants: growth patterns, nutrition and epigenetic markers. A pilot study
| Autor: | Angela Michelucci, Francesca Lorenzoni, Cinzia Cosini, Maria Giulia Tozzi, Paolo Ghirri, Francesca Moscuzza, Massimiliano Ciantelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neonatal intensive care unit medicine.medical_treatment Physiology Pediatrics 03 medical and health sciences 0302 clinical medicine IC1 methylation 030225 pediatrics Medicine Epigenetics growth patterns Original Research epigenetics business.industry Growth factor extrauterine growth restriction growth patterns nutrition IC1 methylation epigenetics lcsh:RJ1-570 Gestational age lcsh:Pediatrics Methylation Phenotype 030104 developmental biology nutrition extrauterine growth restriction Pediatrics Perinatology and Child Health DNA methylation business Reprogramming |
| Zdroj: | Frontiers in Pediatrics Frontiers in Pediatrics, Vol 6 (2018) |
| Popis: | Background/Aims: IntraUterine (IUGR) and ExtraUterine Growth Restriction (EUGR) may induce reprogramming mechanisms, finalized to survive before and after birth. Nutritional factors and other environmental signals could regulate gene expression through epigenetic modification, but the molecular mechanisms involved are not yet well understood. Epigenetic mechanisms could be considered as a bridge between environmental stimuli and long lasting phenotype, acquired during the intrauterine life and the first weeks of life. Our aim was to investigate the relationship between growth patterns, nutritional determinants, and epigenetic pathways.Methods: We enrolled 38 newborns admitted to Neonatal Intensive Care Unit (NICU) at University Hospital of Pisa. Gestational age at birth was 1 SD. We also evaluated DNA methylation of Imprinting Centre 1 (IC1) at birth and at discharge.Results: We observed a decrease in SD of weight and head circumference mainly during the first weeks of life. We found a correlation between EUGR for weight and for head circumference and an increased IC1 methylation (p = 0.018 and p = 0.0028, respectively). We observed a relationship between reduced protein and lipid intake and IC1 hypermethylation (p = 0.009 and p = 0.043, respectively).Conclusion: IC1 hypermethylation could be a reprogramming mechanism to promote a catch-up growth, by means of an increased Insulin-like growth factor 2 (IGF2) expression, that may have potential effects on metabolic homeostasis later in life. |
| Databáze: | OpenAIRE |
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