Continuous infusion of proinflammatory cytokines into the brain to study brain cytokine induced local and systemic immune effects
| Autor: | Britta Schöning, Christian Woiciechowsky, Wolfgang R. Lanksch, Peter Elepfandt, Hans-Dieter Volk |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Fever Neuroimmunomodulation medicine.medical_treatment Central nervous system Inflammation Proinflammatory cytokine Cerebral Ventricles Rats Sprague-Dawley Immune system Meningoencephalitis Medicine Animals Infusions Parenteral business.industry Interleukin-6 Tumor Necrosis Factor-alpha General Neuroscience Interleukin Infusion Pumps Implantable Rats Disease Models Animal medicine.anatomical_structure Neuroimmunology Cytokine Hypothalamus Anterior Immunology Tumor necrosis factor alpha Microglia medicine.symptom business Sleep Interleukin-1 |
| Zdroj: | Brain research. Brain research protocols. 4(2) |
| ISSN: | 1385-299X |
| Popis: | Proinflammatory cytokines are produced in the brain after various kinds of insult (ischemia, trauma, infection). In this process interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α are most important. These cytokines are key mediators of inflammation. Furthermore, these cytokines can act as neurotransmitters and develop direct effects on the central nervous system (CNS) including fever, sleep and stimulation of the neuroendocrine as well as sympathetic nervous system. Moreover, IL-1β and TNF-α may also be involved in brain repair and regenerating processes. However, most of the data about the role of cytokines in the brain have been obtained from either in vitro studies or bolus injections into the brain parenchyma or cerebroventricular system. On the other hand, it is known that cytokines are released continuously into the brain after a cerebral insult over a period of 24 to 48 h. In order to further complete the knowledge about the interactions between neural and immune cells to overcome the primary insult and initiate repair and regeneration in the CNS, a new animal model of local inflammation reaction was established using chronic intracerebral infusion of rat recombinant cytokines. Themes : Endocrine and autonomic regulation Topics : Neural-immune interactions |
| Databáze: | OpenAIRE |
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