Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC)

Autor: Catherine Faucher, Jean-Baptiste Thibert, John De Vos, Christine Giraud, Caroline Ballot, Valérie Mialou, Irina Ionescu, Marie-Thérèse Rubio, Bernard Dazey, Virginie Persoons, Eliane Gluckman, Chantal Kenzey, Jean-Hugues Dalle, Jérôme Larghero, Annalisa Ruggeri, Gérard Michel, Audrey Cras, Fernanda Volt, Jacques-Olivier Bay, Federico Garnier, Evelyne Marry, Vanderson Rocha, Fabienne Pouthier, Christian Chabannon, Hanadi Rafii, Eric Gautier, Danièle Bensoussan
Přispěvatelé: Recherche clinique appliquée à l'hématologie ((EA_3518)), Université Paris Diderot - Paris 7 (UPD7), Centre Scientifique de Monaco (CSM), Agence de la biomédecine [Saint-Denis la Plaine], IRCCS San Raffaele Scientific Institute [Milan, Italie], Etablissement français du sang - Normandie (EFS), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang Nouvelle Aquitaine [Bordeaux] (EFS Bordeaux Nouvelle Aquitaine), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Etablissement Français du Sang Ile de France (EFS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Henry Mondor, Etablissement français du sang [Poitiers] (EFS), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Etablissement français du sang- Rhône-Alpes [Lyon], Etablissement Français du Sang [Grenoble] (EFS), Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC), Etablissement français du sang [Rennes] (EFS Bretagne), Hôpital Robert Debré Paris, Hôpital Robert Debré, Hôpital de la Timone [CHU - APHM] (TIMONE), Universidade de São Paulo = University of São Paulo (USP), CHU Clermont-Ferrand, Service d'Hématologie [CHRU Nancy], Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2021
Předmět:
Zdroj: Bone Marrow Transplantation
Bone Marrow Transplantation, 2021, 56 (10), pp.2497-2509. ⟨10.1038/s41409-021-01313-x⟩
ISSN: 1476-5365
0268-3369
Popis: The public French Cord Blood Banks Network was established in 1999 with the objective of standardizing the practices governing umbilical cord blood (UCB) banking in France. The Network adopted a strategy to optimize its inventory and improve the quality of its banked units based on a quality improvement process using outcome data regularly provided by Eurocord. This study aimed to describe the results, over 10 years, of UCBT facilitated by a national network that used the same criteria of UCB collection and banking and to assess how modifications of banking criteria and unit selection might influence transplant outcomes. Nine hundred and ninety-nine units (593 single-unit and 203 double-unit grafts) were released by the Network to transplant 796 patients with malignant (83%) and non-malignant (17%) diseases. Median cell dose exceeded 3.5 × 107 TNC/kg in 86%. There was a trend to select units more recently collected and with higher cell dose. Neutrophil engraftment was 88.2% (85.7–90.7) and 79.3% (72.6–86.5) respectively for malignant and non-malignant diseases with a trend to faster recovery with higher cell doses. The respective 3-year transplant-related mortality were 31.1% (27.5–35.1) and 34.3% (27.0–43.5). OS was 49% ± 4 in malignant and 62% ± 4 in non-malignant disorders. In multivariate analysis, cell dose was the only unit-related factor associated with outcomes. Our results reflect the benefit on clinical outcomes of the strategy adopted by the Network to bank units with higher cell counts.
Databáze: OpenAIRE
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