Severe cervical inflammation and high-grade squamous intraepithelial lesions: a cross-sectional study
| Autor: | Yue Hu, Gui He, Lingli Long, Wen Zhao, Xiaofang Lu, Zhongqiu Lin, Tengfei Long, lingling Xie, Yubin Li, Ying Tuo, Yaxiao Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Cross-sectional study Squamous Intraepithelial Lesions Uterine Cervical Neoplasms Inflammation Malignancy Cervical intraepithelial neoplasia Gastroenterology High-Grade Squamous Intraepithelial Lesions Lesion 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Atypical Squamous Cells of the Cervix Humans Prospective Studies Aged Aged 80 and over Vaginal Smears 030219 obstetrics & reproductive medicine business.industry Incidence (epidemiology) Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Uterine Cervical Dysplasia Cross-Sectional Studies 030220 oncology & carcinogenesis Female medicine.symptom Abnormality business |
| Zdroj: | Archives of gynecology and obstetrics. 303(2) |
| ISSN: | 1432-0711 |
| Popis: | Inflammation has been reported as a facilitator in cervical oncogenesis, but the correlation between inflammation and cytological abnormality remains uncertain. The aim of this study was to investigate the correlation between inflammation and cytological abnormality. ThinPrep cytological test (TCT) was used to detect cervical cytological abnormalities and inflammation degrees of 46,255 women in this prospective cross-sectional study. Histopathological examination was used to define the cervical intraepithelial neoplasia (CIN) in patients with cervical cytological abnormalities. The study revealed that 8.87% (4102/46,255) of TCT results had cytological abnormalities. The 4102 included cases were classified as the case group, including atypical squamous cells (ASC), low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL). Women with negative intraepithelial lesion or malignancy (NILM) were classified as the control group. About 88.83% (3644/4102) of women with cytological abnormalities showed inflammations. The rate of severe inflammation was significantly higher in the case group than the control group (23.86% vs. 2.0%, P = 0.000). Our results also showed that patients with severe inflammation had a significantly increasing incidence of cytological abnormality by 12.598 times and elevated the risk of HSIL by 756.47 times, compared to the inflammation negative group. Severe inflammation was positively related to HSIL. Patients with severe cervical inflammation should be given more follow-ups and regular examinations and treated more carefully than those with mild or no inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink