Intra-, para-, and suprasellar nuclear protein of testis carcinoma with infiltration of cavernous sinus and clivus-a case report
| Autor: | Stefanos Voglis, Lazar Tosic, Luca Regli, Anna Maria Reuss, Elisabeth J. Rushing, Carlo Serra |
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| Přispěvatelé: | University of Zurich, Tosic, Lazar |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty 10208 Institute of Neuropathology Pulmonary insufficiency 610 Medicine & health Lesion 10180 Clinic for Neurosurgery Clivus Testis medicine Carcinoma Humans NUT midline carcinoma Frozen section procedure business.industry Nuclear Proteins Middle Aged medicine.disease Squamous carcinoma 2746 Surgery medicine.anatomical_structure 2728 Neurology (clinical) Cranial Fossa Posterior Cavernous sinus Carcinoma Squamous Cell Cavernous Sinus Surgery Neurology (clinical) Radiology medicine.symptom business |
| DOI: | 10.5167/uzh-210981 |
| Popis: | A nuclear protein of testis (NUT) carcinoma, also known as NUT midline carcinoma, is a rare subtype of squamous carcinoma known for its aggressive growth behaviour. It can form anywhere in the body. Although, it usually occurs along midline structures (head, neck, lungs). The authors present the first report of intrasellar NUT carcinoma with cavernous sinus infiltration in a 47-year-old patient. MRI showed an inhomogeneous, gadolinium-enhancing lesion with intra- and suprasellar growth, invasion of the cavernous sinus without clear differentiation from normal pituitary tissue. Given the lymphoma diagnosis in the frozen section and invasion of the cavernous sinus, the patient underwent endoscopic, transnasal, and transsphenoidal subtotal resection only. Local tumour and spinal metastases showed a good response to radio-chemotherapy. Despite combined radio-chemotherapy, the patient died of pulmonary insufficiency due to rapid progression of pulmonary metastasis 6 months after the initial diagnosis. |
| Databáze: | OpenAIRE |
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