Multiple myeloma in 16 cats: a retrospective study
| Autor: | Reema T. Patel, Patricia M. McManus, Adrienne F. French, Ana V. Caceres |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Paraproteinemia Pathology medicine.medical_specialty plasmacytic leukemia Plasma Cells Paraproteinemias Hyperglobulinemia Bone Marrow Cells Osteolysis Plasma cell Anemia Hemolytic Congenital Cat Diseases Leukemia Plasma Cell plasmacytoma medicine Animals Multiple myeloma Retrospective Studies General Veterinary business.industry Plasmacytosis Cat Plasma cell neoplasm medicine.disease paraproteinemia multiple myeloma medicine.anatomical_structure Cats Plasmacytoma Original Article Female Plasmacytic leukemia business |
| Zdroj: | Veterinary Clinical Pathology |
| ISSN: | 0275-6382 |
| Popis: | Background: There is limited published information regarding feline multiple myeloma. Diagnostic criteria are derived from canine studies and to our knowledge, have not been critically reviewed for cats. Objective: To evaluate the clinical and laboratory findings in cats with multiple myeloma and appraise diagnostic criteria. Methods: Retrospective evaluation of medical records was performed. Inclusion required an antemortem diagnosis of multiple myeloma using 2 of 4 criteria: 1) ≥20% plasma cells in the bone marrow, or ≥10% if atypical plasma cells; 2) paraproteinemia; 3) radiographically‐evident osteolysis; 4) light chain proteinuria. Alternatively, a postmortem diagnosis was based on the findings of multiple plasma cell neoplasms, with marrow involvement. Results: Sixteen cats were diagnosed with multiple myeloma between 1996 and 2004, with a median age of 14.0 years; 9 of 16 (56%) were castrated males, and 7 of 16 (44%) were spayed females. Laboratory abnormalities included hyperglobulinemia (14/16, 87.5%), with 11/14 (78.5%) monoclonal and 3/14 (21.4%) biclonal gammopathies; hypoalbuminemia (4/16, 25%); light chain proteinuria, (4/9, 44.4%); hypocholesterolemia (11/16, 68.7%); hypercalcemia, (3/15, 20%); nonregenerative anemia, (11/16, 68.7%); regenerative anemia, (1/16, 6.2%); neutropenia (5/15, 33.3%); thrombocytopenia (8/16, 50%); and marrow plasmacytosis (14/15, 93.3%). Plasma cells were markedly immature, atypical, or both in 10 of 12 (83.3%) cats. Focal or multifocal osteolysis was noted in 6 of 12 (50%) cats for which radiographs were available for review; generalized osteopenia was found in 1 (8.3%) cat. Noncutaneous, extramedullary tumors were found in all cats assessed, 7/7 (100%), including spleen (6), liver (3), and lymph nodes (4). The disease in 1 of 2 cats with cutaneous tumors progressed to plasmacytic leukemia. Conclusions: Common findings in feline multiple myeloma include atypical plasma cell morphology, hypocholesterolemia, anemia, bone lesions, and multi‐organ involvement. Based on the results of this study, we advocate modifying diagnostic criteria in cats to include consideration of plasma cell morphology and visceral organ infiltration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text