Adjuvant dose-intense chemotherapy with peripheral blood stem cell support in stage II-III breast cancer with five to nine involved axillary lymph nodes
| Autor: | Raefsky E, Weaver Z, B McAneny, F A Greco, Robert Birch, Lee S. Schwartzberg, John D. Hainsworth, C H Weaver, Buckner Cd, Tauer Kw, J West, R Leff |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Axillary lymph nodes medicine.medical_treatment Breast Neoplasms ThioTEPA Filgrastim Gastroenterology chemistry.chemical_compound Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Adjuvant therapy Humans Etoposide Neoplasm Staging Chemotherapy business.industry Hematopoietic Stem Cell Transplantation Middle Aged medicine.disease Survival Analysis Carboplatin Hematopoietic Stem Cell Mobilization Surgery medicine.anatomical_structure Methotrexate Oncology chemistry Chemotherapy Adjuvant Doxorubicin Lymphatic Metastasis Axilla Female Fluorouracil business medicine.drug |
| Zdroj: | American journal of clinical oncology. 22(2) |
| ISSN: | 0277-3732 |
| Popis: | The purpose of this study is to determine outcomes for patients with high-risk nonmetastatic breast cancer undergoing high-dose chemotherapy with peripheral blood stem cell support. Forty-three patients with stage II-III disease, five to nine positive axillary lymph nodes, and a median age of 44 years (range, 27-60 years) were enrolled in a study that included: 1) standard dose doxorubicin, 5-fluorouracil, and methotrexate adjuvant therapy; 2) cyclophosphamide, etoposide, filgrastim, and peripheral blood stem cell harvest; and 3) high-dose cyclophosphamide, thiotepa, and carboplatin (CTCb) followed by peripheral blood stem cell infusion. All 43 patients received doxorubicin, 5-fluorouracil, and methotrexate, 42 (98%) received etoposide, and 41 (95%) received CTCb. Thirty-two patients (74%) are alive, 28 (65%) without relapse at a median of 55 months (range, 41-87 months). Two died (5%) of treatment-related causes, (subclavian catheter complication after etoposide and late radiation pneumonitis), and nine other deaths (21%) were associated with recurrent breast cancer. The probabilities of overall and event-free survival at 4 years were 0.77 and 0.67, respectively, compared with 0.82 and 0.69, respectively, for 72 similar patients with 10 or more positive axillary nodes receiving the same sequence of therapy. Thus, patients with five to nine positive axillary lymph nodes have a similar risk of failure after high-dose chemotherapy and peripheral blood stem cell support as patients with 10 or more positive axillary lymph nodes. |
| Databáze: | OpenAIRE |
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