Simian virus 40-associated fatal interstitial pneumonia and renal tubular necrosis in a rhesus monkey
| Autor: | S. S. Kalter, Lundy Braun, Keerti V. Shah, W. Douglas Sheffield, John D. Strandberg |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Pathology medicine.medical_specialty viruses Simian virus 40 Thymus Gland Simian Virus Immunoenzyme Techniques Antigen medicine Immunology and Allergy Animals Lung Kidney biology Immunoperoxidase Pneumonia Pneumocystis Acute Kidney Injury Kidney Tubular Necrosis Acute biology.organism_classification Virology Macaca mulatta Basophilic Infectious Diseases medicine.anatomical_structure Lymph Nodes Rabbits Papovavirus Spleen |
| Zdroj: | The Journal of infectious diseases. 142(4) |
| ISSN: | 0022-1899 |
| Popis: | Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were positive for antigen of simian virus 40 by immunoperoxidase staining of paraffin sections of affected organs. Electron microscopy revealed characteristic papovarirus particles in these tissues. This study is the first report indicating that simian virus 40 may produce pulmonary and renal disease in its natural host. |
| Databáze: | OpenAIRE |
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