Aortic aneurysm in patients with functionally normal or minimally stenotic bicuspid aortic valve
| Autor: | Kwan-Leung Chan, Anthony L. Weinberg, Roman T. Pachulski |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Aortic valve
Male medicine.medical_specialty Dissection (medical) Doppler echocardiography Aortic aneurysm Bicuspid aortic valve Aneurysm Internal medicine medicine.artery medicine Humans Aorta medicine.diagnostic_test business.industry Aortic Valve Stenosis medicine.disease Surgery Aortic Aneurysm medicine.anatomical_structure Echocardiography Aortic valve stenosis Aortic Valve cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American journal of cardiology. 67(8) |
| ISSN: | 0002-9149 |
| Popis: | Bicuspid aortic valve (BAV) is the most common form of congenital valvular disease, with a prevalence of approximately 1 to 2% in the general population.1 Aortic coarctation is often associated with BAV.1 A recent editorial by Lindsay2 has drawn attention once again to the concept that BAV and aortic coarctation may be manifestations of a single developmental anomaly—namely, aortic medial fragility. This idea was initially proposed by Abbot3 in 1928, revived by McKusick4 in 1972, and supported by circumstantial evidence referred to by Lindsay in his editorial. To prove that aortic medial fragility underlies BAV and aortic coarctation, one must demonstrate the presence of a pathologic or clinical correlate of aortic medial fragility in patients with the index conditions. The proposed pathologic correlate, cystic medial necrosis, is nonspecific. The clinical correlates of aortic medial fragility include aortic dilatation (aneurysm) or dissection. Although the data cited by Lindsay are suggestive of an increased prevalence of aortic dilatation/ dissection with BAV and coarctation, they could be expressions of the hemodynamic alterations accompanying the index conditions rather than manifestations of aortic medial fragility. To eliminate the confounding influence of hemodynamic disturbances, we studied the prevalence of aortic root dilatation (aneurysm) in patients with a functionally normal or minimally stenotic BAV. This study was to determine whether the aortic root at the sinus level is significantly dilated in patients with a functionally normal or minimally stenotic BAV, which we define as a resting mean aortic valve gradient |
| Databáze: | OpenAIRE |
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