Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase
| Autor: | Zhengping Jia, Suhail Asrar, Guijin Lu, Hisaaki Takahashi, Toshikazu Nakamura, Yu Zhang, Jinsong Meng, Yanghong Meng |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Hippocampus
macromolecular substances Protein Serine-Threonine Kinases Biology environment and public health Lim kinase Mice Cellular and Molecular Neuroscience Cerebellum Animals Phosphorylation Mice Knockout Pharmacology Microfilament Proteins Lim Kinases Zinc Fingers Cofilin Actin cytoskeleton Cell biology DNA-Binding Proteins Kinetics Destrin Actin Depolymerizing Factors Synapses Knockout mouse Excitatory postsynaptic potential Protein Kinases Neuroscience |
| Zdroj: | Neuropharmacology. 47:746-754 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2004.06.030 |
| Popis: | To investigate the role of the LIM-kinase (LIMK) family in the regulation of ADF/cofilin phosphorylation and synaptic function in the mammalian central nervous system (CNS), we conducted biochemical and electrophysiological analysis using mice that were genetically altered in the expression of LIMK-1 and LIMK-2. We showed here that while LIMK-2 knockout mice exhibited minimal abnormalities, the LIMK-1/2 double knockout mice were more severely impaired in both ADF/cofilin phosphorylation and excitatory synaptic function in the CA1 region of the hippocampus. These results indicate a critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain. |
| Databáze: | OpenAIRE |
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