Difference in patterns of retinal ganglion cell damage between primary open-angle glaucoma and non-arteritic anterior ischaemic optic neuropathy
| Autor: | Yeon Hee Lee, Dong Won Heo, Kyoung Nam Kim, Sung Bok Lee, Tae Seen Kang, Chang-Sik Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Retinal Ganglion Cells Eye Diseases genetic structures Vision Visual Acuity Social Sciences Glaucoma lcsh:Medicine Diagnostic Radiology Optic neuropathy chemistry.chemical_compound Nerve Fibers 0302 clinical medicine Anterior ischaemic optic neuropathy Animal Cells Medicine and Health Sciences Psychology lcsh:Science Tomography Neurons Multidisciplinary Radiology and Imaging Middle Aged Ganglion medicine.anatomical_structure Neurology Retinal ganglion cell Female Sensory Perception Anatomy Cellular Types Arteritic anterior ischaemic optic neuropathy Glaucoma Open-Angle Tomography Optical Coherence Research Article medicine.medical_specialty Open angle glaucoma Imaging Techniques Ocular Anatomy Optic Neuropathy Research and Analysis Methods Optic Disc 03 medical and health sciences Ocular System Diagnostic Medicine Ophthalmology medicine Humans Optic Neuropathy Ischemic Aged business.industry lcsh:R Biology and Life Sciences Retinal Cell Biology medicine.disease eye diseases Neuropathy chemistry Case-Control Studies Cellular Neuroscience 030221 ophthalmology & optometry Eyes lcsh:Q sense organs business Head 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 12, Iss 10, p e0187093 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Purpose To compare the patterns of retinal ganglion cell damage between primary open-angle glaucoma (POAG) and non-arteritic anterior ischaemic optic neuropathy (NAION). Methods In total, 35 eyes with unilateral NAION, and 70 age- and average peripapillary retinal nerve fibre layer (RNFL) thickness-matched eyes with POAG, were enrolled as disease groups; 35 unaffected fellow eyes of the NAION, and 70 age- and refractive error-matched normal subjects for the POAG, were enrolled as their control groups, respectively. The peripapillary RNFL thickness and macular ganglion cell plus inner plexiform layer (GCIPL) thickness were compared between the disease groups and their controls, and between the two disease groups. Results Mean RNFL thicknesses at the 1 and 2 o’clock (superonasal) positions were thinner in NAION than in POAG (both p < 0.05). Mean RNFL thickness at 7 o’clock (inferotemporal) was thinner in POAG than in NAION (p = 0.001). Although there was no significant difference between NAION and POAG in average GCIPL thickness, all of the sectoral GCIPL thicknesses were thinner in NAION (all p < 0.05), except in the inferior and inferotemporal sectors. The ranges of the clock-hour RNFL with damage greater than the average RNFL thickness reduction, versus fellow eyes and control eyes, were 7 hours in NAION and 4 hours in POAG. Conclusions The more damaged clock-hour RNFL regions differed between NAION (1 and 2 o’clock) and POAG (7 o’clock). Most sectoral GCIPL thicknesses were thinner in NAION than in POAG. |
| Databáze: | OpenAIRE |
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