Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus
| Autor: | Hye Kwon Kim, Dae Gwin Jeong, Shien-Young Kang, Yong Gun Choi, Ji Yeong Noh, Sun-Woo Yoon, Ji Hyung Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
animal structures viruses lcsh:Medicine Neuraminidase Biology Cross Reactions Virus Article 03 medical and health sciences Phylogenetics Genus Neutralization Tests Chiroptera Republic of Korea Animals lcsh:Science Phylogeny Antiserum Multidisciplinary Paramyxoviridae Infections Phylogenetic tree lcsh:R Isolation (microbiology) Virology In vitro 3. Good health Parainfluenza Virus 1 Human Mice Inbred C57BL Human Parainfluenza Virus 030104 developmental biology Paramyxoviridae lcsh:Q Female |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-30319-7 |
| Popis: | The bat paramyxovirus B16-40 was first isolated in Korea in this study. Using the isolated virus, we could obtain not only genomic information, but also several biological characteristics of the virus. In the phylogenetic analysis, the virus was found to belong to the recently proposed genus Shaanvirus. Through sequence analyses and in vitro testing, the isolated virus was also found to have haemagglutinin-neuraminidase (HN) protein as one of the structural proteins. When mouse antiserum was generated against the isolated virus and tested, it was cross-reactive to human parainfluenza virus 1 in an indirect immunofluorescence assay but could not cross-neutralize human parainfluenza virus 1. In addition, the bat paramyxovirus B16-40 was not infectious in the mouse model. Collectively, this study provided basic information on further classification of the bat paramyxovirus B16-40 and related viruses in the proposed genus Shaanvirus. |
| Databáze: | OpenAIRE |
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