Is calmodulin inhibition involved in shape transformations induced by amphiphiles in erythrocytes?
| Autor: | Ann Christine Engblom, Boris Isomaa |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Erythrocytes
Calmodulin biology Chemistry Chlorpromazine Biophysics Phosphodiesterase Shape transformation Cell Biology Calcium Channel Blockers Biochemistry Phosphodiesterase I Red blood cell Kinetics medicine.anatomical_structure 3' 5'-Cyclic-AMP Phosphodiesterases Amphiphile medicine biology.protein Humans Phosphodiesterase activity Inhibitory effect |
| Zdroj: | Biochimica et biophysica acta. 940(1) |
| ISSN: | 0006-3002 |
| Popis: | Potent antihaemolytic and shape transforming amphiphilic compounds were studied for their ability to inhibit calmodulin-activated phosphodiesterase activity. Some echinocytogenic and stomatocytogenic amphiphiles were potent calmodulin inhibitors. The most potent echinocytogenic and stomatocytogenic amphiphiles, however, had no or only weak inhibitory effect. Our results show that there is no causal relationship between the ability of amphiphiles to induce antihaemolysis or shape transformation in erythrocytes and their ability to inhibit calmodulin-activated phosphodiesterase activity, and it is suggested that calmodulin is not involved in shape transformation induced by amphiphiles. |
| Databáze: | OpenAIRE |
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