Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy
| Autor: | Jean-François Le Bas, François Estève, Sylvie Grand, Christophe Rubin, Hélène Kolodié |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Cancer Research Magnetic Resonance Spectroscopy Metabolite medicine.medical_treatment Brain tumor Creatine Choline Central nervous system disease chemistry.chemical_compound medicine Humans Radiology Nuclear Medicine and imaging Irradiation Lactic Acid Radiation Injuries Aspartic Acid Radiation business.industry Brain Neoplasms Brain Human brain Middle Aged medicine.disease Radiation therapy medicine.anatomical_structure Oncology chemistry Female Nuclear medicine business |
| Zdroj: | International journal of radiation oncology, biology, physics. 40(2) |
| ISSN: | 0360-3016 |
| Popis: | Purpose To observe the time course of the proton magnetic resonance spectroscopy (1H-MRS) variations due to radiation therapy on normal human brain. Methods and materials We followed 11 patients receiving an exclusive external radiation therapy for brain tumor for 8 months. They underwent proton MRS scans before any radiation exposure and 1, 4, and 8 months after they began the radiation therapy. The patients received 60 Gy in tumoral area fractionated over 6 weeks. The contralateral normal brain hemisphere received a radiation dose from 20 to 50 Gy. The main metabolite concentrations (N-acetylaspartate (NAA), choline compounds (Cho), creatine (Cr), and lactate (Lac) were evaluated by the areas of the peaks after peak fitting. Normalized values (NV) were obtained by processing the ratio of the peak area of a given metabolite to the sum of all the spectrum peak areas; ratios (NAA/Cho, NAA/Cr, and Cho/Cr) were processed. One patient, who received panencephalic radiotherapy (30 Gy) after metastasectomy from a primary kidney adenocarcinoma, has been monitored with 1H-MRS eight times for 6 months to observe the onset of the metabolic changes. Results Changes were observed in irradiated normal brain tissue 4 months after radiation therapy began: the NAA/Cho and NAA/Cr ratios and the NAA (NV) decreased while the Choline (NV) increased. Four months later, normal values were recovered. Conclusion 1H-MRS has the potentiality to detect and to evaluate in vivo early adverse metabolic effects of radiation therapy in the normal human brain. These changes are significant 4 months after the radiation therapy began and appear to resolve over time. |
| Databáze: | OpenAIRE |
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