Myasthenia gravis and pregnancy: retrospective evaluation of 27 pregnancies in a tertiary center and comparison with previous studies
| Autor: | Erdem Fadiloglu, Atakan Tanacan, Mehmet Sinan Beksac, Gonca Ozten, Gokcen Orgul, Ali Can Gunes |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Fetal Membranes Premature Rupture medicine.medical_specialty Exacerbation Birth weight Gestational Age 030204 cardiovascular system & hematology Miscarriage 03 medical and health sciences 0302 clinical medicine Pregnancy Myasthenia Gravis Birth Weight Humans Medicine 030212 general & internal medicine Retrospective Studies Cesarean Section business.industry Obstetrics Infant Newborn Pregnancy Outcome Gestational age General Medicine medicine.disease Myasthenia gravis Abortion Spontaneous Pregnancy Complications Premature Birth Female Apgar score business Postpartum period |
| Zdroj: | Irish Journal of Medical Science (1971 -). 188:1261-1267 |
| ISSN: | 1863-4362 0021-1265 |
| Popis: | To share our experience with the management of pregnancies in women with myasthenia gravis (MG) in a tertiary center. The study retrospectively evaluated 27 pregnancies in 12 patients. The pregnancies were divided into 3 groups on the basis of the clinical course of MG during pregnancy: improvement (n = 7), disease-stable (n = 9), and deterioration (n = 11). The groups were compared with respect to patient characteristics, clinical features, and obstetric outcomes. There were 4 miscarriages (14.8%), 3 preterm births (11.1%), and 4 cases of preterm premature rupture of the membranes (PPROM) (14.8%). Exacerbation was observed in 25.9% of the cases; the remission rate during the postpartum period and after miscarriage was 37%. The cesarean section (CS) rate was 78.3%. Pregnancies with deterioration of MG were statistically more likely to have higher miscarriage, preterm birth, PPROM, CS, and transient neonatal MG rates, in addition to a lower gestational age at birth, birth weight, and 5-min Apgar score than pregnancies with improved or stable disease (p values |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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