Multisession Radiosurgery for Hearing Preservation
| Autor: | Jeffrey H. Kim, Dalong Pang, Sean P. Collins, Walter C. Jean, Abdul Rashid, Jimm Grimm, Sana D. Karam, Beenish Rashid |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Hearing loss medicine.medical_treatment Acoustic neuroma Radiation Dosage Radiosurgery Lower risk Radiation Tolerance Young Adult 03 medical and health sciences 0302 clinical medicine Cyberknife medicine Humans Radiology Nuclear Medicine and imaging Fraction (mathematics) Hearing Loss Aged Aged 80 and over business.industry Dose fractionation Neuroma Acoustic Middle Aged medicine.disease Cochlea Surgery Treatment Outcome Risk Estimate Oncology 030220 oncology & carcinogenesis Female Dose Fractionation Radiation medicine.symptom business Nuclear medicine 030217 neurology & neurosurgery |
| Zdroj: | Seminars in Radiation Oncology. 26:105-111 |
| ISSN: | 1053-4296 |
| DOI: | 10.1016/j.semradonc.2015.11.004 |
| Popis: | Clinically relevant dose-tolerance limits with reliable estimates of risk in 1-5 fractions for cochlea are still unknown. Timmerman׳s limits from the October 2008 issue of Seminars in Radiation Oncology have served as the basis for clinical practice, augmented by updated constraints in TG-101 and QUANTEC, but the corresponding estimates of risk have not yet been well-reported. A total of 37 acoustic neuroma CyberKnife cases from Medstar Georgetown University Hospital treated in 3 or 5 fractions were combined with single-fraction Gamma Knife data from the 69 cases in Timmer 2009 to form an aggregate dataset of 106 cochlea cases treated in 1-5 fractions. Probit dose-response modeling was performed in the DVH Evaluator software to estimate normal tissue complication probability. QUANTEC recommends keeping single-fraction maximum dose to the cochlea less than 14Gy to maintain less than 25% risk of serviceable hearing loss, and our 17.9% risk estimate for 14Gy in 1 fraction is within their predicted range. In 5 fractions, our estimate of the Timmerman 27.5Gy maximum cochlea dose limit was 17.4%. For cases in which lower risk is required, the Timmerman 12Gy in 1 fraction and the TG-101 limit of 25Gy in 5 fractions had an estimated risk level of 11.8% and 13.8%, respectively. High-risk and low-risk dose tolerance with risk estimates in 1-5 fractions are all presented. |
| Databáze: | OpenAIRE |
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