Brain positron emission tomography in patients with myotonic dystrophy type 1 and type 2

Autor: Vera Ilic, Ivana Basta, Vidosava Rakocevic Stojanovic, Biljana Salak-Djokic, Leposava Brajković, Stojan Peric, Bozidar Belanovic
Rok vydání: 2017
Předmět:
Adult
Male
musculoskeletal diseases
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Neuropsychological Tests
Grey matter
Myotonic dystrophy
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Internal medicine
medicine
Brain positron emission tomography
Humans
Myotonic Dystrophy
0501 psychology and cognitive sciences
Cognitive deficit
Brain Mapping
medicine.diagnostic_test
business.industry
05 social sciences
Neuropsychology
Brain
Middle Aged
medicine.disease
Glucose
medicine.anatomical_structure
Neurology
Positron emission tomography
Positron-Emission Tomography
Cardiology
Female
Neurology (clinical)
Radiopharmaceuticals
medicine.symptom
business
Insula
030217 neurology & neurosurgery
Executive dysfunction
Zdroj: Journal of the Neurological Sciences. 378:187-192
ISSN: 0022-510X
DOI: 10.1016/j.jns.2017.05.013
Popis: To determine regions of reduced brain metabolism in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) using 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET), and to analyse their potential association with cognitive deficit.Study included 29 patients (16 DM1 and 13 DM2). FDG-PET and detailed neuropsychological testing were performed in both groups.The most common cognitive findings were executive, visuospatial, and naming dysfunction in DM1, and executive and naming dysfunction in DM2. FDG-PET showed the most prominent glucose hypometabolism in prefrontal, temporal, and pericentral regions in both DM1 and DM2 patients, with additional affection of insula and subcortical grey matter in DM2. In DM1 patients, we found association between right frontotemporal hypometabolism and executive dysfunction (p0.05). In DM2 patients attention deficit was in association with prefrontal, insular, and striatal hypometabolism, as well as right frontotemporal hypometabolism (p0.05). Executive dysfunction in DM2 was more common in patients with prefrontal and insular hypometabolism, right parietotemporal and frontotemporal hypometabolism, as well as left striatal hypometabolism (p0.05). Patients with parietotemporal defect on FDG-PET were more likely to have naming dysfunction (p0.01).FDG-PET findings corresponded well with the results of neuropsychological testing. FDG-PET may be a good biomarker of central nervous system involvement in DM1 and DM2, but this hypothesis will have to be more strongly supported by larger studies.
Databáze: OpenAIRE
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