The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats
| Autor: | M R Grigor, K R Gain |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
History
medicine.medical_specialty Serum insulin Mammary gland Dehydrogenase Glucosephosphate Dehydrogenase Education Mammary Glands Animal Malate Dehydrogenase Pregnancy Internal medicine medicine Lipogenic enzymes Animals Lactation Starvation chemistry.chemical_classification biology Rats Inbred Strains Prolactin Computer Science Applications Rats Fatty acid synthase Endocrinology Enzyme medicine.anatomical_structure chemistry Liver Food biology.protein Female medicine.symptom Fatty Acid Synthases Research Article |
| Popis: | Lactating rats were starved for 48 h and refed a high-carbohydrate diet for a further 48 h. Starvation stops milk secretion, which resumes shortly after refeeding. Three lipogenic enzymes, fatty acid synthase, glucose 6-phosphate dehydrogenase (EC 1.1.1.49) and ‘malic’ enzyme (EC 1.1.1.40) all decrease in the mammary gland during starvation and are restored to the pre-starvation levels 48 h after refeeding. The same enzymes in liver also decrease during starvation, but increase to values significantly higher than those for the normal fed rats after refeeding the high-carbohydrate diet. For the fatty acid synthase these values were four times the pre-starvation values. Serum insulin and prolactin concentrations also increased upon refeeding the high-carbohydrate diet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|