Factors that predict disease severity in atopic dermatitis: The role of serum basal tryptase
| Autor: | Betul Buyuktiryaki, Abdullah Turasan, Neriman Sahiner, Bulent Enis Sekerel, Hatice Eke Gungor, Yasemin Altuner Torun, Umit Murat Sahiner |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Adolescent Tryptase 01 natural sciences Gastroenterology Severity of Illness Index Dermatitis Atopic Atopy 03 medical and health sciences Leukocyte Count Young Adult 0302 clinical medicine Interquartile range Risk Factors Internal medicine medicine Immunology and Allergy Humans SCORAD 0101 mathematics Child biology medicine.diagnostic_test business.industry 010102 general mathematics General Medicine Odds ratio Atopic dermatitis Eosinophil Immunoglobulin E medicine.disease Prognosis Confidence interval Eosinophils medicine.anatomical_structure 030228 respiratory system ROC Curve Case-Control Studies biology.protein Female Tryptases business Biomarkers |
| Zdroj: | Allergy and asthma proceedings. 39(5) |
| ISSN: | 1539-6304 |
| Popis: | BACKGROUND Increased numbers of mast cells that contain tryptase are found in lesional atopic dermatitis (AD) skin. The association of serum basal tryptase (sBT) with anaphylactic reactions and mast cell diseases has recently been shown in children with venom and food allergy. OBJECTIVE We aimed to identify the risk factors that predict the severity of AD and the association of sBT levels with AD and disease severity. METHOD AD diagnosis was made according to Hanifin and Rajka criteria. Disease severity was scored by the objective scoring atopic dermatitis (SCORAD) index. The sBT levels were measured. Skin-prick testing, total immunoglobulin E, eosinophil percentages and counts, and a questionnaire concerning the history of atopic diseases and the risk factors of AD were applied. RESULTS The children, ages 0.5 to 3.0 years, with AD (n = 85) were analyzed in two groups according to the presence (AD+/atopy+ [n = 55]) or absence (AD+/atopy- [n = 30]) of skin-prick test positivity. The comparisons were made with an age- and sex-matched control group (n = 82). The median (interquartile range) sBT in the AD+/atopy+, AD+/atopy-, and control groups were 5.01 ng/mL (2.75-6.79 ng/mL), 3.02 ng/mL (1.67-4.44 ng/mL), and 2.63 ng/mL (1.31-4.49 ng/mL), respectively (p = 0.003). The median (interquartile range) sBT levels were higher in patients with moderate-severe objective SCORAD index scores compared with the those with mild disease (3.85 ng/mL [2.04-5.91 ng/mL] versus 2.80 ng/mL [1.83-3.48 ng/mL]; p = 0.038). Multivariate logistic regression analysis showed that an sBT level of ≥3.9 ng/mL (odds ratio 8.77 [95% confidence interval, 1.87-41.18]; p = 0.006) was independently associated with an increased risk of moderate-severe AD (objective SCORAD index). CONCLUSION To our knowledge, this was the first study that indicated that sBT levels may be important in the AD disease process and associated with the disease severity and atopy. |
| Databáze: | OpenAIRE |
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