Liver Enzyme and Adipocytokine Profiles are Synergistically Associated with Insulin Resistance: the J-SHIPP Study
| Autor: | Rie Takita, Katsuhiko Kohara, Tomoko Kido, Tetsuro Miki, Yasuharu Tabara, Eri Uetani, Namiko Ochi, Michiya Igase |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Population Adipokine Enzyme-Linked Immunosorbent Assay Insulin resistance Adipokines Asian People Japan Liver enzyme Internal medicine Internal Medicine Humans Medicine Longitudinal Studies Prospective Studies Prospective cohort study education Aged education.field_of_study Adiponectin business.industry Leptin Biochemistry (medical) Alanine Transaminase gamma-Glutamyltransferase Prognosis medicine.disease Cross-Sectional Studies Endocrinology Liver Female Insulin Resistance Cardiology and Cardiovascular Medicine business Biomarkers Homeostasis |
| Zdroj: | Journal of Atherosclerosis and Thrombosis. 19:577-584 |
| ISSN: | 1880-3873 1340-3478 |
| DOI: | 10.5551/jat.11924 |
| Popis: | AIM Alanine aminotransferase (ALT) and γ-glutamyltransferase (GGT) are associated with insulin resistance and arteriosclerotic disease. Since adiposity raises liver enzyme levels and causes insulin resistance, adipocytokines are thought to underlie the relationship between liver enzymes and insulin resistance. To clarify this hypothesis, we conducted a cross-sectional epidemiological study in a Japanese general population. METHODS The study subjects were 903 middle-aged to elderly persons. Plasma levels of adiponectin and leptin were measured, while other clinical parameters were obtained from personal health records of medical check-ups. Insulin resistance was assessed by a homeostasis model assessment index (HOMA-IR). RESULTS Plasma levels of ALT (r=0.379, p |
| Databáze: | OpenAIRE |
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