Metabolism of Progesterone in the Canine Feto-Placental Unit
| Autor: | Faith Ellen Francis, Ralph A. Kinsella, Gerhard H. Muelheims |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Chromatography Gas Placenta medicine.medical_treatment Biology General Biochemistry Genetics and Molecular Biology Dogs Fetus Pregnancy Internal medicine medicine Animals Intestinal Mucosa Lung Maternal-Fetal Exchange Chromatography High Pressure Liquid Progesterone Uterus Brain Gravid uterus Metabolism medicine.disease Steroid hormone Uterine circulation Endocrinology Liver Female Perfusion Hormone |
| Zdroj: | Experimental Biology and Medicine. 196:301-306 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-196-43192 |
| Popis: | Progesterone (P), a major hormone of pregnancy, was selected for study under the conditions of an intact utero-placental-fetal unit. A preparation of the canine gravid uterus, near term, is described and shown to permit observation of the metabolic relationships of the steroid hormone P between maternal and fetal organisms. [1,2-3H] P or [7α-3H]P was injected into pups, while [4-14C]P was injected into the uterine circulation. Perfusion was continued for 1 hr with excellent survival of the pups. Identified metabolites in the fetal and maternal tissues suggest a metabolic pool that is shared throughout the unit. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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