Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: Part 2

Autor:	Malcolm MacKenny, Andrews Mark David, Jean-Yves Chiva, Mark Ian Lansdell, Alan Daniel Brown, David W. Gordon, David Sebastien Fradet
Rok vydání:	2009
Předmět:	Clinical Biochemistry Pharmaceutical Science behavioral disciplines and activities Biochemistry Structure-Activity Relationship Dopamine Uptake Inhibitors Litoxetine mental disorders Drug Discovery Serotonin Uptake Inhibitors Molecular Biology Serotonin Plasma Membrane Transport Proteins Adrenergic Uptake Inhibitors Chemistry digestive oral and skin physiology Organic Chemistry Highly selective Combinatorial chemistry Antidepressive Agents Drug Design Benzene derivatives Molecular Medicine Serotonin Selective Serotonin Reuptake Inhibitors
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:5893-5897
ISSN:	0960-894X
Popis:	A second wave of potential SSRIs with high ease of synthetic accessibility were designed based on the reported selective serotonin re-uptake inhibitor litoxetine and our own previous work in this area. Preparation and subsequent optimisation yielded a range of potent and highly selective SSRIs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65c2d79d41795b3aabf7fbb65e21d96 https://doi.org/10.1016/j.bmcl.2009.08.066 Zobrazit plný text záznamu Full Text from ScienceDirect