Effect of peer health workers on AIDS care in Rakai, Uganda: a cluster-randomized trial

Autor: Arnold H. Packer, Gertrude Nakigozi, Thomas C. Quinn, Robert C. Bollinger, Steven J. Reynolds, Joseph Kagaayi, David Serwadda, Victor Ssempijja, Ronald H. Gray, Larry W. Chang
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Anti-HIV Agents
Health Personnel
Public Health and Epidemiology/Infectious Diseases
lcsh:Medicine
Peer Group
law.invention
03 medical and health sciences
Young Adult
0302 clinical medicine
Pharmacotherapy
Randomized controlled trial
Acquired immunodeficiency syndrome (AIDS)
law
Medicine
Cluster Analysis
Humans
Uganda
030212 general & internal medicine
Cluster randomised controlled trial
Young adult
lcsh:Science
Aged
Acquired Immunodeficiency Syndrome
030505 public health
Multidisciplinary
Intention-to-treat analysis
business.industry
lcsh:R
Public Health and Epidemiology/Global Health
Middle Aged
Viral Load
Infectious Diseases/HIV Infection and AIDS
medicine.disease
Confidence interval
3. Good health
Relative risk
Patient Compliance
Female
lcsh:Q
0305 other medical science
business
Research Article
Zdroj: PLoS ONE, Vol 5, Iss 6, p e10923 (2010)
PLoS ONE
ISSN: 1932-6203
Popis: Background Human resource limitations are a challenge to the delivery of antiretroviral therapy (ART) in low-resource settings. We conducted a cluster randomized trial to assess the effect of community-based peer health workers (PHW) on AIDS care of adults in Rakai, Uganda. Methodology/Principal Findings 15 AIDS clinics were randomized 2∶1 to receive the PHW intervention (n = 10) or control (n = 5). PHW tasks included clinic and home-based provision of counseling, clinical, adherence to ART, and social support. Primary outcomes were adherence and cumulative risk of virologic failure (>400 copies/mL). Secondary outcomes were virologic failure at each 24 week time point up to 192 weeks of ART. Analysis was by intention to treat. From May 2006 to July 2008, 1336 patients were followed. 444 (33%) of these patients were already on ART at the start of the study. No significant differences were found in lack of adherence (
Databáze: OpenAIRE