Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study
| Autor: | Kunihiro Sonoda, Yuka Kono, Kazuya Kitamori, Kazuo Ohtake, Sachiko Shiba, Keizo Kasono, Jun Kobayashi |
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| Rok vydání: | 2022 |
| Předmět: |
nonalcoholic fatty liver disease
angiotensin II type 1 receptor Liver Cirrhosis Captopril angiotensin II Diet High-Fat digestive system endothelial dysfunction Catalysis Inorganic Chemistry nitric oxide nitrate Non-alcoholic Fatty Liver Disease Rats Inbred SHR Animals nonalcoholic steatohepatitis Physical and Theoretical Chemistry nitrite Molecular Biology Spectroscopy Nitrites captopril nicotinamide adenine dinucleotide phosphate oxidase Organic Chemistry nutritional and metabolic diseases General Medicine digestive system diseases Computer Science Applications Rats Disease Models Animal Cholesterol Liver |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 2931 |
| ISSN: | 1422-0067 |
| Popis: | Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the liver and the cardiovascular system. Here, we evaluated the effect of dietary nitrite on a rat NASH model. Stroke-prone, spontaneously hypertensive 5/Dmcr rats were fed a high-fat/high-cholesterol diet to develop the NASH model, with nitrite or captopril (100 mg/L, each) supplementation in drinking water for 8 weeks. The effects of nitrite and captopril were evaluated using immunohistochemical analyses of the liver and heart tissues. Dietary nitrite suppressed liver fibrosis in the rats by reducing oxidative stress, as measured using the protein levels of nicotinamide adenine dinucleotide phosphate oxidase components and inflammatory cell accumulation in the liver. Nitrite lowered the blood pressure in hypertensive NASH rats and suppressed left ventricular chamber enlargement. Similar therapeutic effects were observed in a captopril-treated rat NASH model, suggesting the possibility of a common signaling pathway through which nitrite and captopril improve NASH pathology. In conclusion, dietary nitrite attenuates the development of NASH with cardiovascular involvement in rats and provides an alternative NASH therapeutic strategy. p.16 Article number: 2931 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Databáze: | OpenAIRE |
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