Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank
| Autor: | Feifei Cheng, Ronald C.W. Ma, Elaine Chow, Juliana C.N. Chan, Risa Ozaki, Alice P.S. Kong, Qiao Jin, Cadmon K.P. Lim, Theresa Yeung, Alicia J. Jenkins, Tammy Tak-Yee So, Eric S.H. Lau, Andrea O.Y. Luk, Kit-Man Loo |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Type 2 diabetes Fluorescence Endocrinology Interquartile range Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Clinical endpoint Humans Prospective Studies Prospective cohort study Biological Specimen Banks Skin business.industry Proportional hazards model fungi Skin autofluorescence medicine.disease Diabetes Mellitus Type 2 Cardiovascular Diseases Heart failure Hong Kong business |
| Zdroj: | Journal of diabetes and its complications. 35(10) |
| ISSN: | 1873-460X |
| Popis: | Aims To investigate association between skin autofluorescence (SAF) and cardiovascular events (CVE) and assess its predictive value in Chinese adults with type 2 diabetes (T2D). Materials and methods SAF was measured non-invasively in 3806 Chinese adults with T2D between 2016 and 2019 with CVE as primary endpoint and individual components as secondary endpoints. Cox proportional hazard models were used to examine associations between SAF and endpoints with adjustment for conventional risk factors. C-statistic, integrated discrimination improvement (IDI), and net reclassification improvement (NRI) were performed to evaluate SAF's predictive value. Results During a median 1.8 (interquartile range, 1.2–3.1) years of follow-up, 172 individuals experienced CVE. Multivariate Cox model showed that SAF was independently associated with CVE (HR 1.18 per SD, 95% CI [1.02, 1.37]), coronary heart disease (HR 1.29 per SD, 95% CI [1.02, 1.63]), and congestive heart failure (HR 1.53 per SD, 95% CI [1.14, 2.05]). SAF yielded additional value on CVE risk stratification with enhanced IDI (95% CI) (0.023 [0.001, 0.057]) and continuous NRI (0.377 [0.002, 0.558]) over traditional risk factors. Conclusions Higher SAF was independently associated with CVE in Chinese adults with T2D and yielded incremental predictive information for CVE. SAF has potential as a prognostic maker for CVE. |
| Databáze: | OpenAIRE |
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