Evaluation of microRNA-124 expression in renal cell carcinoma
| Autor: | A Ötünçtemur, G Öztürk, Sadrettin Pence, H Alsaadoni, Burcu Çaykara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty QH426-470 law.invention 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma law Internal medicine microRNA expression medicine Genetics Genetics (clinical) Polymerase chain reaction 030304 developmental biology 0303 health sciences Kidney business.industry Wnt signaling pathway microrna-124 (mir-124) medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Biomarker (medicine) Original Article Cancer development business renal cell carcinoma (rcc) Body mass index |
| Zdroj: | Balkan Journal of Medical Genetics, Vol 23, Iss 2, Pp 73-78 (2021) Balkan Journal of Medical Genetics : BJMG |
| ISSN: | 1311-0160 |
| Popis: | The Wingless/INT (WNT) signaling network has roles in renal cancer development. It was shown that the tumor-suppressor microRNA-124 (miR-124) is associated with the Wnt pathway. Thus, we aimed to measure miR-124 expression levels to evaluate whether it is a prognostic marker or a potential treatment strategy. Thirty tumor and 30 surrounding healthy kidney tissues from the same subjects diagnosed with renal cell carcinoma (RCC), were included in the study. The expression levels of miR-124 were measured with real-time polymerase chain reaction (qPCR) and determined by the 2–ΔΔCT method. The Statistical Package for Social Science (SPSS) version 22 program was used for statistical analyses and a p value of 0.05 was considered to be statistically significant. The expression levels of miR-124 was found to be about 3-fold lower in tumors than in healthy tissues (p 0.001) and decreased expression levels correlated with tumor stage, tumor diameter, body mass index (BMI) and neutrophil values (p 0.05). Our results showed that miR-124 expression levels are associated with RCC. MicroRNA-124 may be assessed as a biomarker in prognosis and the restoration of miR-124 expression might be effective in the treatment of RCC. |
| Databáze: | OpenAIRE |
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