Assessment of Optic Nerve Head Pallor in Primary Open-Angle Glaucoma Patients and Healthy Subjects

Autor:	Martin Hammer, Lutz E Pillunat, Naim Terai, Eberhard Spörl, Lydia Sauer, Richard Stodtmeister, Lisa Ramm, Birte Schwab
Rok vydání:	2017
Předmět:	Male 0301 basic medicine medicine.medical_specialty genetic structures Open angle glaucoma Fundus Oculi Optic Disk Glaucoma Pallor 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Ophthalmology medicine Humans In patient Fluorescein Angiography Intraocular Pressure Aged business.industry Healthy subjects Retinal Vessels Middle Aged medicine.disease Healthy Volunteers eye diseases Sensory Systems Surgery Absolute deviation Vessel diameter Cross-Sectional Studies 030104 developmental biology 030221 ophthalmology & optometry Optic nerve Visual Field Tests Female sense organs Visual Fields medicine.symptom business Glaucoma Open-Angle Tomography Optical Coherence
Zdroj:	Current Eye Research. 42:1313-1318
ISSN:	1460-2202 0271-3683
DOI:	10.1080/02713683.2017.1307415
Popis:	To investigate optic nerve head (ONH) pallor quantitatively in patients with primary open-angle glaucoma (POAG) and in healthy subjects, and to examine the relationship to mean deviation in perimetry (MD), cup-disk ratio (CDR), and diameters of retinal vessels.A total of 89 POAG patients (67.6 ± 11.1 years) and 48 healthy subjects (63.3 ± 14 years) were included. A dual-bandpass transmission filter was introduced in the illumination path of the fundus camera of the Dynamic Vessel Analyzer (Imedos Systems UG) and two monochromatic images at different wavelenghts (548 ± 10 and 610 ± 10 nm) were recorded simultaneously. ONH pallor was defined as the quotient of light reflection in both spectral channels. Pallor values were averaged over four fields which were positioned on the ONH. The mean of these measurements was calculated. In 47 of 89 POAG patients diameters of retinal vessels were determined peripapillary.In POAG, the ONH showed a significantly higher pallor value compared to healthy subjects (82.34 ± 19.28 vs. 62.67 ± 10.41, p0.001). ONH pallor was correlated to indicators used to estimate disease severity: MD (r = -0.565, p0.001) and CDR (r = 0.561, p0.001). The pallor value was associated to diameters of retinal arterioles (r = -0.313, p = 0.032) and venules (r = -0.397, p = 0.006).Pallor determined by this method was higher in POAG patients than in healthy subjects and increased in patients with advanced disease. ONH pallor might result from a reduced blood perfusion of the ONH or tissue atrophy accompanied by vessel obliteration in POAG. By measuring ONH pallor additional diagnostic information about the vitality of the neuroretinal rim might be gained in glaucoma patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65556e26af0f1298412383657116913 https://doi.org/10.1080/02713683.2017.1307415 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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