Estimation of kinetic parameters without input functions: analysis of three methods for multichannel blind identification
| Autor: | E.V.R. Di Bella, D.Y. Riabkov |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Quality Control
Blind deconvolution Mathematical optimization Finite impulse response Iterative method Biomedical Engineering Models Biological Sensitivity and Specificity Transfer function Convolution Image Processing Computer-Assisted Medical imaging Humans Computer Simulation Tissue Distribution Radioactive Tracers Mathematics Likelihood Functions Stochastic Processes business.industry Reproducibility of Results Signal Processing Computer-Assisted Pattern recognition Image Enhancement Magnetic Resonance Imaging Identification (information) Deconvolution Artificial intelligence Radiopharmaceuticals business Algorithms Tomography Emission-Computed |
| Zdroj: | IEEE Transactions on Biomedical Engineering. 49:1318-1327 |
| ISSN: | 0018-9294 |
| DOI: | 10.1109/tbme.2002.804588 |
| Popis: | Compartment modeling of dynamic medical image data implies that the concentration of the tracer over time in a particular region of the organ of interest is well modeled as a convolution of the tissue response with the tracer concentration in the blood stream. The tissue response is different for different tissues while the blood input is assumed to be the same for different tissues. The kinetic parameters characterizing the tissue responses can be estimated by multichannel blind identification methods. These algorithms use the simultaneous measurements of concentration in separate regions of the organ; if the regions have different responses, the measurement of the blood input function may not be required. Three blind identification algorithms are analyzed here to assess their utility in medical imaging: eigenvector-based algorithm for multichannel blind deconvolution; cross relations; and iterative quadratic maximum-likelihood (IQML). Comparisons of accuracy with conventional (not blind) identification techniques where the blood input is known are made as well. Tissue responses corresponding to a physiological two-compartment model are primarily considered. The statistical accuracies of estimation for the three methods are evaluated and compared for multiple parameter sets. The results show that IQML gives more accurate estimates than the other two blind identification methods. |
| Databáze: | OpenAIRE |
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