Electroacupuncture relieves neuropathic pain via upregulation of glutamate transporters in the spinal cord of rats
| Autor: | Yan Feng, Lu-ying Cui, Ming-xing Ding, Jie Zeng |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pyrrolidines Electroacupuncture medicine.medical_treatment Pharmacology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Extracellular fluid medicine Animals Dicarboxylic Acids Acupuncture Analgesia RNA Messenger business.industry General Neuroscience Chronic pain Glutamate receptor Nerve injury medicine.disease Spinal cord Up-Regulation Excitatory Amino Acid Transporter 1 030104 developmental biology medicine.anatomical_structure Excitatory Amino Acid Transporter 2 Spinal Cord Anesthesia Neuropathic pain Neuralgia medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 620:38-42 |
| ISSN: | 0304-3940 |
| Popis: | Glutamate transports (GTs), the only vehicle for removal of glutamate from the extracellular fluid, is reported to be related to chronic pain. To investigate whether the glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) participate in electroacupuncture (EA) analgesia, the EA effect was observed with paw withdraw threshold in a rat model of spared nerve injury. The expression levels of GLAST and GLT-1 were determined with Western Blot and RT-PCR. The results showed significantly upregulated GLAST and GLT-1, along with the relieved pain behaviors after EA treatment. In addition, intrathecal injection of GTs inhibitor, l-trans-pyrrolidine-2-4-dicarboxylate, attenuated the EA-induced analgesic effect. The experiment demonstrates that EA can increase the GTs of neuropathic pain rats, which might be one of the mechanisms underlying its effectiveness in the neuropathic pain. |
| Databáze: | OpenAIRE |
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