Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy
| Autor: | Elizabeth M. Kanter, Darrel L. Ellis, Richard B. Beaven, Chad A. Lieber, Joanne Hutchings, Shovan K. Majumder, Anita Mahadevan-Jansen, Matthew D. Keller, Nicholas Stone |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pathology
Skin Neoplasms Clinical Biochemistry Cell Culture Techniques Uterine Cervical Neoplasms Cervix Uteri Spectrum Analysis Raman raft cultures Neoplasms Glandular and Epithelial Skin lcsh:R5-920 skin cancer field effect General Medicine Middle Aged medicine.anatomical_structure Cell Transformation Neoplastic Raman spectroscopy symbols Disease Progression Female spectral markers lcsh:Medicine (General) malignancy associated changes Adult medicine.medical_specialty Adolescent Malignancy Sensitivity and Specificity symbols.namesake dysplasia cervix Genetics medicine Biomarkers Tumor Humans Molecular Biology Cervix Aged business.industry Biochemistry (medical) Disease progression optical diagnosis Histology Raft culture medicine.disease Raman microspectroscopy Dysplasia Other business |
| Zdroj: | Disease Markers, Vol 25, Iss 6, Pp 323-337 (2008) Disease markers |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined through four separate but related studies. Results from a clinical cervix study show that previous disease has a significant effect on the Raman signatures of the cervix, which allow for near 100% classification for discriminating previous disease versus a true normal. A Raman microspectroscopy study showed that Raman can detect changes due to adjacent regions of dysplasia or HPV that cannot be detected histologically, while a clinical skin study showed that Raman spectra may be detecting malignancy associated changes in tissues surrounding nonmelanoma skin cancers. Finally, results of an organotypic raft culture study provided support for both the skin and thein vitrocervix results. These studies add to the growing body of evidence that optical spectroscopy, in this case Raman spectral markers, can be used to detect subtle temporal and spatial effects in tissue near cancerous sites that go otherwise undetected by conventional histology. |
| Databáze: | OpenAIRE |
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