Comparison of laser-Doppler flowmetry with biochemical indicators of endothelial dysfunction related to early microangiopathy in Type 1 diabetic patients
| Autor: | Tomas Haas, Bohdana Kalvodová, Jan Škrha, Jan Kvasnička, Martin Prázný |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Hot Temperature Endothelium beta-N-Acetyl-Galactosaminidase Endocrinology Diabetes and Metabolism Hyperemia Gastroenterology Microcirculation Endocrinology Reference Values Diabetes mellitus Internal medicine Laser-Doppler Flowmetry Internal Medicine medicine Humans Endothelial dysfunction Reactive hyperemia business.industry Microangiopathy Middle Aged Intercellular Adhesion Molecule-1 medicine.disease Constriction Forearm Diabetes Mellitus Type 1 Hexosaminidases medicine.anatomical_structure Beta-N-Acetyl-Galactosaminidase Female Microalbuminuria Endothelium Vascular E-Selectin business Biomarkers Diabetic Angiopathies |
| Zdroj: | Journal of Diabetes and its Complications. 15:234-240 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/s1056-8727(01)00152-0 |
| Popis: | The aim of this study was to compare biochemical markers of endothelial activation with microcirculation measured by laser-Doppler flowmetry in Type 1 diabetic patients with or without microangiopathy. A total of 44 Type 1 diabetic patients were subdivided into those with (n=24) and without (n=20) microangiopathy according to ophthalmological findings and the presence or absence of microalbuminuria. The control group consisted of 25 healthy people of comparable age, sex, and body mass index. Postocclusive reactive hyperemia (PORH) and thermal hyperemia (TH, at 44 degrees C) were measured at the forearm. Serum N-acetyl-beta-glucosaminidase (NAG) activity, serum E-selectin, and ICAM-1 concentrations were used as biochemical markers of endothelial dysfunction. A significantly lower velocity of perfusion increase during postocclusive hyperemia (PORH(max) x t(1)(-1)) and during thermal hyperemia (TH(max) x t(2)(-1)) (P |
| Databáze: | OpenAIRE |
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