Perinatal outcome of pregnancies complicated by placental chorioangioma: a systematic review and meta-analysis

Autor: D. Buca, M. Sirotkina, Alexander Makatsariya, C. Iacovella, Giuseppe Rizzo, Asma Khalil, Marco Liberati, Ganesh Acharya, Francesco D'Antonio, Claudia Silvi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
medicine.medical_specialty
Polyhydramnios
Placenta Diseases
Anemia
Hydrops Fetalis
Perinatal Death
chorioangioma
Prenatal diagnosis
placental tumors
Ultrasonography
Prenatal
law.invention
fetal therapy
prenatal diagnosis
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Pregnancy
medicine.artery
Medicine
Humans
Radiology
Nuclear Medicine and imaging
030212 general & internal medicine
Perinatal Mortality
Fetus
030219 obstetrics & reproductive medicine
Radiological and Ultrasound Technology
business.industry
Obstetrics
Infant
Newborn
Pregnancy Outcome
Obstetrics and Gynecology
General Medicine
medicine.disease
Reproductive Medicine
Meta-analysis
Hyperdynamic circulation
Middle cerebral artery
Female
Settore MED/40 - Ginecologia e Ostetricia
business
Hemangioma
Pregnancy Complications
Neoplastic
Popis: OBJECTIVE To report the perinatal outcome of singleton pregnancies complicated by placental chorioangioma diagnosed on prenatal ultrasound. METHODS MEDLINE, EMBASE, CINAHL and ClinicalTrials.gov databases were searched for studies reporting the outcome of pregnancies complicated by placental chorioangioma. Inclusion criteria were singleton pregnancy diagnosed with placental chorioangioma on prenatal ultrasound, with no other associated structural anomaly. The primary outcome was perinatal mortality. Secondary outcomes included associated non-structural anomalies detected on prenatal ultrasound (including fetal hydrops, anemia, polyhydramnios, signs of hyperdynamic circulation and small-for-gestational-age (SGA) fetus), SGA at birth, composite neonatal morbidity and preterm birth. Outcome was assessed separately in pregnancies undergoing and those not undergoing fetal therapy. Subanalyses were performed according to the presence of hydrops and the size of the tumor in all pregnancies diagnosed with chorioangioma. Random-effects meta-analyses of proportions were used to analyze the data. RESULTS Twenty-eight studies (161 pregnancies) were included. In pregnancies complicated by chorioangioma that did not undergo intervention, intrauterine death occurred in 8.2% (95% CI, 3.8-15.0%), while neonatal death and perinatal death occurred in 3.8% (95% CI, 1.0-8.1%) and 11.1% (95% CI, 5.0-19.4%), respectively. SGA at birth was present in 24.0% (95% CI, 13.5-36.5%) of cases, while preterm birth
Databáze: OpenAIRE
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