Assessment of semiquantitative parameters of dynamic contrast-enhanced perfusion MR imaging in differentiation of subtypes of renal cell carcinoma
| Autor: | Nabil N, Farouk A, Abdel Razek Aa, Amani Ezzat Mousa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Cellular differentiation Chromophobe cell carcinoma urologic and male genital diseases 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma medicine Carcinoma magnetic resonance imaging Carcinoma Renal Cell medicine.diagnostic_test business.industry Magnetic resonance imaging Cell Differentiation medicine.disease Magnetic Resonance Imaging female genital diseases and pregnancy complications renal cell cell differentiation 030220 oncology & carcinogenesis Original Article medicine.symptom business Perfusion Clear cell |
| Zdroj: | Polish Journal of Radiology |
| Popis: | Summary Background To assess semiquantitative parameters of dynamic contrast-enhanced perfusion MR imaging (DCE) in differentiation of subtypes of renal cell carcinoma (RCC). Material/Methods Prospective study conducted upon 34 patients (27 M, 7 F, aged 25–72 ys: mean 45 ys) with RCC. Abdominal dynamic contrast-enhanced gradient-recalled echo MR sequence after administration of gadopentetate dimeglumine was obtained. The time signal intensity curve (TIC) of the lesion was created with calculation of enhancement ratio (ER), and washout ratio (WR). Results The subtypes of RCC were as follows: clear cell carcinomas (n=23), papillary carcinomas (n=6), and chromophobe carcinomas (n=5). The mean ER of clear cell, papillary and chromophobe RCC were 188±49.7, 35±8.9, and 120±41.6 respectively. The mean WR of clear cell, papillary and chromophobe RCCs were 28.6±6.8, 47.6±5.7 and 42.7±10, respectively. There was a significant difference in ER (P=0.001) and WR (P=0.001) between clear cell RCC and other subtypes of RCC. The threshold values of ER and WR used for differentiating clear cell RCC from other subtypes of RCC were 142 and 38 with areas under the curve of 0.937 and 0.895, respectively. Conclusions We concluded that ER and WR are semiquantitative perfusion parameters useful in differentiation of clear cell RCC from chromophobe and papillary RCCs. |
| Databáze: | OpenAIRE |
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