Are Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum Associated With Specific Genital Symptoms and Clinical Signs in Nonpregnant Women?
| Autor: | Rosie L. Latimer, Michelle Doyle, Eric P F Chow, Catriona S. Bradshaw, Christopher K Fairley, Erica L Plummer, Kaveesha Bodiyabadu, Matthew S. Payne, Suzanne M. Garland, Lenka A. Vodstrcil, Gerald L. Murray |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Vaginal discharge medicine.medical_specialty 030106 microbiology Mycoplasma hominis medicine.disease_cause Ureaplasma 03 medical and health sciences 0302 clinical medicine medicine Humans Mycoplasma Infections 030212 general & internal medicine biology Obstetrics business.industry Ureaplasma Infections Ureaplasma infection medicine.disease biology.organism_classification Infectious Diseases Ureaplasma parvum medicine.anatomical_structure Vagina Female Bacterial vaginosis medicine.symptom business Ureaplasma urealyticum |
| Zdroj: | Clinical Infectious Diseases. 73:659-668 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciab061 |
| Popis: | Background There is limited evidence supporting an association between Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum with symptoms or disease in nonpregnant women. However, testing and reporting of these organisms frequently occurs, in part due to their inclusion in multiplex-PCR assays for sexually transmitted infection (STI) detection. We investigated if M. hominis, U. urealyticum, and U. parvum were associated with symptoms and/or signs in nonpregnant women attending a sexual health service. Methods Eligible women attending the Melbourne Sexual Health Centre completed a questionnaire regarding sexual practices and symptoms. Symptomatic women underwent examination. Women were assessed for bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC), and tested for M. hominis, U. urealyticum, and U. parvum, and 4 nonviral STIs using a commercial multiplex-PCR. Results 1272 women were analyzed. After adjusting for STIs and VVC, M. hominis was associated with abnormal vaginal discharge (aOR = 2.70, 95%CI:1.92–3.79), vaginal malodor (aOR = 4.27, 95%CI:3.08–5.91), vaginal pH > 4.5 (aOR = 4.27, 95%CI:3.22–5.66), and presence of clue cells (aOR = 8.08, 95%CI:5.68–11.48). Ureaplasma spp. were not associated with symptoms/signs. Bacterial vaginosis was strongly associated with M. hominis (aOR = 8.01, 95%CI:5.99–10.71), but was not associated with either Ureaplasma spp. In stratified analyses, M. hominis was associated with self-reported vaginal malodor and clinician-recorded vaginal discharge in women with BV, but not with symptoms/signs in women without BV. Conclusions Only M. hominis was associated with symptoms/signs, and these were manifestations of BV. Importantly, M. hominis was not associated with symptoms/signs in women without BV. These findings do not support routine testing for M. hominis, U. urealyticum, and U. parvum in nonpregnant women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|